Cullen, Tom, Thomas, A.W., Webb, R. and Hughes, M.G. (2016) Interleukin-6 and Associated Cytokine Responses to An Acute Bout of High-intensity Interval Exercise: the Effect of Exercise Intensity and Volume. Applied Physiology, Nutrition, and Metabolism, 41 (8). pp. 803-808. ISSN 1715-5312 Online: 1715-5320
Text
Interleukin-6 and associated cytokine responses to an acute bout of high intensity interval exercise.pdf_sequence=3&isAllowed=y - Accepted Version Download (329kB) |
Abstract
Acute increases in interleukin (IL)-6 following prolonged exercise are associated with the induction of a transient anti-inflammatory state (e.g., increases in IL-10) that is partly responsible for the health benefits of regular exercise. The purposes of this study were to investigate the IL-6–related inflammatory response to high-intensity interval exercise (HIIE) and to determine the impact of exercise intensity and volume on this response. Ten participants (5 males and 5 females) completed 3 exercise bouts of contrasting intensity and volume (LOW, MOD, and HIGH). The HIGH protocol was based upon standard HIIE protocols, while the MOD and LOW protocols were designed to enable a comparison of exercise intensity and volume with a fixed duration. Inflammatory cytokine concentrations were measured in plasma (IL-6, IL-10) and also determined the level of gene expression (IL-6, IL-10, and IL-4R) in peripheral blood. The plasma IL-6 response to exercise (reported as fold changes) was significantly greater in HIGH (2.70 ± 1.51) than LOW (1.40 ± 0.32) (P = 0.04) and was also positively correlated to the mean exercise oxygen uptake (r = 0.54, P < 0.01). However, there was no change in anti-inflammatory IL-10 or IL-4R responses in plasma or at the level of gene expression. HIIE caused a significant increase in IL-6 and was greater than that seen in low-intensity exercise of the same duration. The increases in IL-6 were relatively small in magnitude, and appear to have been insufficient to induce the acute systemic anti-inflammatory effects, which are evident following longer duration exercise.
Item Type: | Article |
---|---|
Additional Information: | This is a post-print version of the article. |
Uncontrolled Discrete Keywords: | nutrition and dietetics, physiology (medical), physiology, endocrinology, diabetes and metabolism, general medicine |
Subjects: | R Medicine > RM Therapeutics. Pharmacology |
Divisions: | College of Business, Psychology and Sport > School of Sport and Exercise Science |
Related URLs: | |
SWORD Depositor: | Prof. Pub Router |
Depositing User: | Karol Kosinski |
Date Deposited: | 02 Nov 2017 10:25 |
Last Modified: | 17 Jun 2020 17:20 |
URI: | https://eprints.worc.ac.uk/id/eprint/6026 |
Actions (login required)
View Item |