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Article

Doughty, Angela, Keane, Gary, Wadley, Alex, Mahoney, Berenice ORCID: https://orcid.org/0000-0002-7414-8185, Bueno, Allain ORCID: https://orcid.org/0000-0002-9456-8558 and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2024) Plasma concentrations of thioredoxin, thioredoxin reductase and peroxiredoxin-4 can identify high risk patients and predict outcome in patients with acute coronary syndrome: a clinical observation. International Journal of Cardiology. pp. 1-36. ISSN 0167-5273 (print) 1874-1754 (web)

de Carvalho, J.F., Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 and Bueno, Allain ORCID: https://orcid.org/0000-0002-9456-8558 (2023) Vitamin B12 (cobalamin) supplementation for the management of autoimmune rheumatic diseases: potential indications and opportunity for future research. Rheumatology International. ISSN Print: 0172-8172 Online: 1437-160X

Hillier, James, Allcott, Gemma, Guest, Laura, Heaselgrave, Wayne, Tonks, Alex, Conway, Myra, Cherry, Amy ORCID: https://orcid.org/0000-0002-8222-1071 and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2022) The BCAT1 CXXC Motif Provides Protection Against ROS in Acute Myeloid Leukaemia Cells. Antioxidants, 11 (4). p. 683. ISSN 2076-3921

Rastogi, N., Baker, S., Man, S., Uger, R., Wong, M., Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Hodges, M., Gilkes, A., Knapper, S., Darley, R. and Tonks, A. (2021) Use of an anti-CD200 blocking antibody improves immune responses to AML in vitro and in vivo. British Journal of Haematology, 193 (1). pp. 155-159. ISSN 1365-2141

Wadley, Alex, Cullen, Tom, Vautrinot, Jordan, Keane, Gary, Bishop, N.C. and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2020) High intensity interval exercise increases the frequency of peripheral PD-1+ CD8+ central memory T-cells and soluble PD-L1 in humans. Brain Behaviour and Immunity: Health, 3. Article no. 100049. ISSN 2666-3546

Heaselgrave, W., Hamad, A., Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 and Hau, S. (2019) In Vitro Evaluation of the Inhibitory Effect of Topical Ophthalmic Agents on Acanthamoeba Viability. Translational Vision Science and Technology, 8 (5). Article no. 17. ISSN 2164-2591

Wadley, A., Keane, Gary, Cullen, Tom, James, L., Vautrinot, Jordon, Davies, Matthew, Hussey, B., Hunter, D.J., Mastana, S., Holliday, A., Petersen, SV., Bishop, N.C., Lindley, M.R. and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2019) Characterisation of Extracellular Redox Enzyme Concentrations in Response to Exercise in Humans. Journal of Applied Physiology, 127 (3). pp. 858-866. ISSN Print: 8750-7587 Online: 1522-1601

Hillier, James, Wadley, A.J., Morgan, R.G., Cherry, Amy ORCID: https://orcid.org/0000-0002-8222-1071, Conway, M.E. and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2018) Identification and Characterisation of a Novel Antioxidant Activity for the BCAT1 Cxxc Motif: Implications for Myeloid Leukaemia Development. Blood, 132. p. 1473. ISSN 00064971

Wadley, A.J., Hole, P., Tonks, A., Darley, R., Omidvar, D., Morgan, R., Gary, Keane and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2018) Intracellular Thiol Oxidation Is Linked with Loss of Δψm and Disease Progression in Acute Promyelocytic Leukaemia. Blood, 132. p. 2751. ISSN 00064971

Wadley, Alex, Morgan, R.G., Heesom, K.J., Hole, P.S. and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2018) Detecting Intracellular Thiol Redox State in Leukaemia and Heterogeneous Immune Cell Populations: an Optimised Protocol for Digital Flow Cytometers. MethodsX, 5. pp. 1473-1483. ISSN 2215-0161

Wadley, Alex, Holliday, Adrian, Morgan, R.G., Heesom, K.J., Aldred, S., Peters, D.M. ORCID: https://orcid.org/0000-0002-7873-7737, Bueno, Allain ORCID: https://orcid.org/0000-0002-9456-8558 and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2018) Preliminary Evidence of Reductive Stress in Human Cytotoxic T-cells Following Exercise. Journal of Applied Physiology, 125 (2). pp. 586-595. ISSN 8750-7587 Online: 1522-1601

Morgan, R.G., Chambers, A., Legge, D.N., Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Greenhough, A. and Williams, A.C. (2018) Optimized Delivery of siRNA Into 3D Tumor Spheroid Cultures in Situ. Scientific Reports, 8 (7952). ISSN 2045-2322

Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2018) Targeting the Immune Checkpoint in Cancer: Is This a Viable Treatment Option for AML? Open Access Journal of Oncology and Medicine, 1 (2). pp. 1-2. ISSN 2638-5945

Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 and Wadley, Alex (2017) Can BCAT1 Expression Level Help Predict Disease Progression in Chronic Lymphocytic Leukaemia. Cancer and Oncology: Open Access Journal, 1 (1).

Wadley, Alex, Aldred, S. and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2016) Mini Review: An Unexplored Role for Peroxiredoxin in Exercise-induced Redox Signalling? Redox Biology, 8. pp. 51-58. ISSN Print: 2213-2317 Online: 2213-2317

Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Gilmour, M.N., Reed, R., Knapper, S., Burnett, A.K., Man, S., Tonks, A. and Darley, R.L. (2015) The Immunosuppressive Ligands PD-L1 and CD200 are Linked in AML T-cell Immunosuppression: Identification of a New Immunotherapeutic Synapse. Leukemia, 29 (9). pp. 1952-1954. ISSN Print: 0887-6924 Online: 1476-5551

Agathanggelou, A., Weston, V.J., Perry, T., Davies, N.J., Skowronska, A., Payne, D.T., Fossey, J.S., Oldreive, C.E., Wei, W., Pratt, G., Parry, H., Oscier, D., Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Hole, P.S., Darley, R.L., McMahon, M., Hayes, J.D., Moss, P., Stewart, G., Taylor, M. and Stankovic, T. (2015) Targeting the Ataxia Telangiectasia Mutated-null Phenotype in Chronic Lymphocytic Leukemia with Pro-oxidants. Haematologica, 100 (8). pp. 1076-1085. ISSN Print: 0390-6078 Online: 1592-8721

Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Hills, R.K., Wang, E.C.Y., Burnett, A.K., Man, S., Darley, R.L. and Tonks, A. (2012) Expression of CD200 on AML Blasts Directly Suppresses Memory T-cell Function. Leukemia, 26 (9). pp. 2148-2151. ISSN Print: 0887-6924 Online: 1476-5551

Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Hills, R.K., Wang, E.C.Y., Burnett, A.K., Man, S., Darley, R.L. and Tonks, A. (2012) Increased CD200 Expression in Acute Myeloid Leukemia is Linked With an Increased Frequency of FoxP3+ Regulatory T Cells. Leukemia, 26 (9). pp. 2146-2148. ISSN Print: 0887-6924 Online: 1476-5551

Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Hancock, J.T. and Conway, M.E. (2012) Differential Redox Potential Between the Human Cytosolic and Mitochondrial Branched-chain Aminotransferase. Acta Biochimica et Biophysica Sinica, 44 (2). pp. 172-176. ISSN Print: 1672-9145 Online: 1745-7270

Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Wang, E.C.Y., Man, S., Hills, R.K., Burnett, A.K., Tonks, A. and Darley, R.L. (2011) CD200 Expression Suppresses Natural Killer Cell Function and Directly Inhibits Patient Anti-tumor Response in Acute Myeloid Leukemia. Leukemia, 25 (5). pp. 792-799. ISSN Print: 0887-6924 Online: 1476-5551

Walsby, E.J., Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Knapper, S. and Burnett, A.K. (2011) The Topoisomerase II Inhibitor Voreloxin Causes Cell Cycle Arrest and Apoptosis in Myeloid Leukemia Cells and Acts in Synergy with Cytarabine. Haematologica, 96 (3). pp. 393-399. ISSN Print: 0390-6078 Online: 1592-8721

Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Easton, P., Sharrod, H., Hutson, S.M., Hancock, J.T., Patel, V.B. and Conway, M.E. (2009) S-Nitrosoglutathione Inactivation of the Mitochondrial and Cytosolic BCAT Proteins: S-nitrosation and S-thiolation. Biochemistry, 48 (3). pp. 645-656. ISSN Print: 0006-2960 Online: 1520-4995

Conway, M.E., Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Islam, M.M. and Hutson, S.M. (2008) Regulatory Control of Human Cytosolic Branched-chain Aminotransferase by Oxidation and S-glutathionylation and its Interactions with Redox Sensitive Neuronal Proteins. Biochemistry, 47 (19). pp. 5465-5479. ISSN Print: 0006-2960 Online: 1520-4995

Book Section

Wadley, A. J. and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2022) Time to ‘Couple’ Redox Biology with Exercise Immunology. In: Oxidative Eustress in Exercise Physiology. Oxidative Stress and Disease . CRC Press, Abingdon, pp. 85-94. ISBN 9780367508760; eBook: 9781003051619

Wadley, A., Morgan, R.G., Darley, R.L., Hole, P.S. and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2019) Using Flow Cytometry to Detect and Measure Intracellular Thiol Redox Status in Viable T Cells from Heterogeneous Populations. In: Redox-Mediated Signal Transduction: Methods and Protocols (2nd Edition). Methods in Molecular Biology . Springer US (Humana Press), New York, NY, pp. 53-70. ISBN Print: 978-1-4939-9461-8 Online: 978-1-4939-9463-2

Hutson, S.M., Poole, L.B., Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 and Conway, M.E. (2009) Redox Regulation and Trapping Sulphenic Acid in the Peroxide Sensitive Human Mitochondrial Branched Chain Aminotransferase. In: Redox-Mediated Signal Transduction: Methods and Protocols. Methods in Molecular Biology . Humana Press, New York, pp. 135-148. ISBN Hardback: 978-1-58829-842-3 Paperback: 978-1-61737-802-7

Conference or Workshop Item

Joyce, Ellen ORCID: https://orcid.org/0000-0002-2595-2898, Machado, Meira, Hirata, Bruna, Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Cherry, Amy ORCID: https://orcid.org/0000-0002-8222-1071, Telles, Monica and Bueno, Allain ORCID: https://orcid.org/0000-0002-9456-8558 (2023) Ginkgo Biloba supplementation modulates dimethyl acetal levels differently in hypothalamus and hippocampus of diet-induced obese rats. In: IBRO 2023, 9th to 13th September 2023, Granada.

Paskin, Samantha, Bueno, Allain ORCID: https://orcid.org/0000-0002-9456-8558, Davis, Sarah K. ORCID: https://orcid.org/0000-0002-4683-4807 and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2023) Relationship between social media exposure, neuropsychological profile and associations with nutritional status and buccal cell fatty acid profile. In: 8th European Congress of Psychology - Psychology: Uniting communities for a sustainable world, 3-6 July 2023, Brighton, UK.

Hillier, James, Brunet, Mathieu, Terry, Rebecca, Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 and Wall, Ivan (2023) The BCAT1 CXXC motif modulates extracellular vesicle release in acute myeloid leukaemia cell line U937. In: International Society for Extracellular Vesicles Annual Meeting, 17th to 21st May 2023, Seattle Convention Centre.

Wilde, Emma, Cramp, S., Wright, M., Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 and Cherry, Amy ORCID: https://orcid.org/0000-0002-8222-1071 (2020) Crosstalk Between Myeloid Leukaemia Factors and Hedgehog Signalling Highlights the Potential for New Treatment Strategies for Leukaemia. In: EuroLeuk 2020, 29-30 October 2020, Online. (Unpublished)

Hillier, James, Heaselgrave, Wayne and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2020) BCAT1 increases sensitivity to Cytarabine and confers CXXC motif derived resistance to pro-oxidant treatment in Acute Myeloid Leukaemiacells. In: British Society for Haematology Annual Scientific Meeting, 26-29th April 2020, Birmingham. ISSN 1365-2141 (Unpublished)

Hillier, James, Wadley, A., Morgan, R., Cherry, Amy ORCID: https://orcid.org/0000-0002-8222-1071, Conway, M.E. and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2018) Identification and Characterisation of a Novel Antioxidant Activity for the BCAT1 Cxxc Motif: Implications for Myeloid Leukaemia Development. In: 60th ASH Annual Meeting & Exposition, 1st - 4th December 2018, San Diego Convention Center, CA, USA. (Unpublished)

Wadley, A., Hole, P., Tonks, A., Darley, R.L., Omidvar, N., Morgan, R., Keane, Gary and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2018) Intracellular Thiol Oxidation Is Linked with Loss of Δψm and Disease Progression in Acute Promyelocytic Leukaemia. In: 60th ASH Annual Meeting & Exposition, 1st - 4th December 2018, San Diego Convention Center, CA, USA. (Unpublished)

Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Gilmour, M.N., Reid, R., Knapper, S., Burnett, A.K., Man, S., Tonks, A. and Darley, R.L. (2014) CD200 and PD1-L1 in AML Are Associated with Expanded PD-1+ Late Differentiated CD8+ T Cells and a Decreased CD4:CD8 Ratio: a New Link Between Distinct Immunosuppressive Pathways. In: 56th American Society of Hematology Annual Meeting and Exposition, 6th - 9th December 2014, San Francisco. (Unpublished)

Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Man, S., Hills, R.K., Wang, E.C.Y., Burnett, A.K., Darley, R.L. and Tonks, A. (2011) CD200 Inhibits Memory Th1 Cell Function in Acute Myeloid Leukaemia (AML). In: Annual Congress of the British Society for Immunology, 5th - 8th December 2011, Liverpool, UK. (Unpublished)

Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Man, S., Hills, R., Wang, E.C.Y., Burnett, A.K., Darley, R.L. and Tonks, A. (2010) Over-expression of CD200 in Acute Myeloid Leukemia Mediates the Expansion of Regulatory T-lymphocytes and Directly Inhibits Natural Killer Cell Tumor Immunity. In: 52nd American Society of Hematology Annual Meeting and Exposition, 4th - 7th December 2010, Orlando, Florida.

Walsby, E.J., Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Knapper, S., Pepper, C. and Burnett, A.K. (2009) Topoisomerase II Inhibitor Voreloxin Causes Cell Cycle Arrest and Apoptosis in Acute Myeloid Leukaemia Cells and Acts in Synergy with Cytarabine. In: 51st American Society of Hematology (ASH) Annual Meeting and Exposition, 5th - 8th December 2009, New Orleans, LA, USA. (Unpublished)

Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Man, S., Wang, E., Burnett, A.K., Darley, R.L. and Tonks, A. (2009) The role of CD200 in AML tumour immunity. In: RUNX Transcription Factors in Development and Disease Annual Meeting, 16-19 August, 2009, Oxford. (Unpublished)

Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Hancock, J.T., Hutson, S.M. and Conway, M.E. (2007) S-nitrosylation of the human branched chain aminotransferase isoenzymes. In: 7th United Kingdom Nitric Oxide Forum, 2007, Bradford. (Unpublished)

Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Hutson, S.M., Hancock, J.T. and Conway, M.E. (2006) S-nitrosylation, redox regulation and the human branched chain aminotransferase (hBCATc). In: Centennial Meeting of the Biochemical Society, 23-27 July, 2006, Glasgow. (Unpublished)

Conway, M.E., Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Islam, M., Mallet, C. and Hutson, S.M. (2006) The human branched chain aminotransferase (hBCATc) differs in sensitivity to peroxide compared to the mitochondrial isofrom. In: Biochemical Society Annual Meeting, 2006. (Unpublished)