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Mini Review: An Unexplored Role for Peroxiredoxin in Exercise-induced Redox Signalling?

Wadley, Alex, Aldred, S. and Coles, Steven ORCID: (2016) Mini Review: An Unexplored Role for Peroxiredoxin in Exercise-induced Redox Signalling? Redox Biology, 8. pp. 51-58. ISSN Print: 2213-2317 Online: 2213-2317

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Peroxiredoxin (PRDX) is a ubiquitous oxoreductase protein with a conserved ionised thiol that permits catalysis of hydrogen peroxide (H2O2) up to a million times faster than any thiol-containing signalling protein. The increased production of H2O2 within active tissues during exercise is thought to oxidise conserved cysteine thiols, which may in turn facilitate a wide variety of physiological adaptations. The precise mechanisms linking H2O2 with the oxidation of signalling thiol proteins (phosphates, kinases and transcription factors) are unclear due to these proteins’ low reactivity with H2O2 relative to abundant thiol peroxidases such as PRDX. Recent work has shown that following exposure to H2O2 in vitro, the sulfenic acid of the PRDX cysteine can form mixed disulphides with transcription factors associated with cell survival. This implicates PRDX as an ‘active’ redox relay in transmitting the oxidising equivalent of H2O2 to downstream proteins. Furthermore, under oxidative stress, PRDX can form high molecular weight structures that can be secreted into the extracellular space, potentially acting as an extracellular ‘stress’ signal. There is extensive literature assessing non-specific markers of oxidative stress in response to exercise, however the PRDX catalytic cycle may offer a more robust approach for measuring changes in redox balance following exercise. This review discusses studies assessing PRDX-mediated cellular signalling and integrates the recent advances in redox biology with investigations that have examined the role of PRDX during exercise in humans and animals. Future studies should explore the role of PRDX as a key regulator of peroxide mediated-signal transduction during exercise in humans.

Item Type: Article
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The full-text of the online published article can be accessed via the Official URL.

Uncontrolled Discrete Keywords: Redox signalling, ROS, exercise, Cysteine, Thiol, Peroxiredoxin
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: College of Health, Life and Environmental Sciences > School of Science and the Environment
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Copyright Info: Open Access journal
Depositing User: Alex Wadley
Date Deposited: 22 Nov 2016 08:02
Last Modified: 17 Jun 2020 17:14

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