Worcester Research and Publications

SEARCH EPRINTS:

USER PANEL:

Registered Users - Log in using your University of Worcester ID and Password to submit items to the repository.

ABOUT THE COLLECTION:

WRaP is a collection of research papers and university publications. It presents the academic and creative work of the university. You are welcome to look for and obtain items of interest and make contact with the authors and creators.

CONTACT DETAILS:

All correspondence about WRaP should be sent to the Repository Manager.

Prodrug to Probe Solution HFA pMDI Formulation and Pulmonary Esterase Activity

Tools

Lists

Seville, Peter C. ORCID: https://orcid.org/0000-0001-8546-3474, Simons, C., Taylor, G. and Dickinson, P.A. (2000) Prodrug to Probe Solution HFA pMDI Formulation and Pulmonary Esterase Activity. International Journal of Pharmaceutics, 195 (1-2). pp. 13-16. ISSN Print: 0378-5173 Online: 1873-3476

Full text not available from this repository. (Request a copy)

Official URL: https://www.sciencedirect.com/science/article/pii/...

Abstract

A novel salbutamol prodrug was synthesised. Solubility in HFA-134a and susceptibility to rat lung homogenate, blood and plasma esterase enzymes were investigated. Whereas salbutamol had a very low solubility in HFA-134a, the prodrug was found to be miscible in all proportions. In lung homogenate, the prodrug hydrolysed with a half-life of 45 min, re-generating approximately 17% of expected salbutamol after 8 h incubation. The use of a solution pMDI for pulmonary delivery of the salbutamol prodrug is predicted to result in liberation of salbutamol in the lungs following in vivo hydrolysis by lung esterases.

Item Type:	Article
Additional Information:	The full-text of the published version cannot be supplied. Please check availability with your local library or Interlibrary Requests service.
Uncontrolled Discrete Keywords:	salbutamol, ester, prodrug, solution, inhaler, lung
Divisions:	College of Health, Life and Environmental Sciences > School of Science and the Environment
Related URLs:	https://www.sciencedirect.com/journal/in...
Depositing User:	Peter Seville
Date Deposited:	17 Jun 2019 09:41
Last Modified:	17 Jun 2020 17:30
URI:	https://eprints.worc.ac.uk/id/eprint/8199

Actions (login required)

View Item

Altmetric

CORE (COnnecting REpositories)

© University of Worcester Henwick Grove, WR2 6AJ Tel: 01905 855000 | Materials in WRaP are protected by copyright and other intellectual property rights. By using WRaP you agree to abide by UK copyright laws.

Worcester Research and Publications is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.