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Isothermic and Fixed-intensity Heat Acclimation Methods Elicit Equal Increases in Hsp72 mRNA

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Gibson, O.R., Mee, Jessica A., Taylor, L., Tuttle, J.A., Watt, P. and Maxwell, N.S. (2015) Isothermic and Fixed-intensity Heat Acclimation Methods Elicit Equal Increases in Hsp72 mRNA. Scandinavian Journal of Medicine & Science in Sports, 25. pp. 259-268. ISSN Online: 1600-0838

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J.Mee_2015_Isothermic and fixed-intensity heat acclimation methods elicit equal increases in Hsp72 mRNA.pdf - Published Version
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Official URL: https://onlinelibrary.wiley.com/doi/full/10.1111/s...

Abstract

Thermotolerance, to which heat shock protein-72 (Hsp72) contributes, is an acquired state achieved following heat acclimation (HA), eliciting cellular adaption and protection against thermal stress. Optimal HA methods achieving the greatest heat shock response (HSR) are equivocal; therefore, investigation of methods pro- voking the greatest sustained HSR is required to optimize cellular adaptation. Twenty-four males performed short- term HA (STHA; five sessions) and long-term HA (LTHA; STHA plus further five sessions) utilizing fixed- intensity (FIXED; workload = 50% V O2 peak ), continuous isothermic HA [ISOCONT; target rectal temperature (Trec) = 38.5 °C], or progressive isothermic HA (ISOPROG; target Trec = 38.5 °C for STHA then target Trec = 39.0 °C for LTHA). Leukocyte Hsp72 mRNA was measured pre- and post day 1, day 5, and day 10 of HA via reverse transcription quantitative polymerase chain reaction to determine the HSR. Hsp72 mRNA increased (P < 0.05) pre- to post day 1, pre- to post day 5, and pre to post day 10 in FIXED, ISOCONT, and ISOPROG, but no differences were observed between methods (P > 0.05). The equal Hsp72 mRNA increases occurring from consistent, reduced, or increased endogenous strain following STHA and LTHA suggest that transcription occurs following attainment of sufficient endogenous criteria. These data give confidence that all reported HA methods increase Hsp72 mRNA and are capable of eliciting adaptations toward thermotolerance.

Item Type:	Article
Additional Information:	Staff and students at the University of Worcester can access the full-text of the online published version via the UW online library search. External users should check availability with their local library or Interlibrary Requests Service.
Uncontrolled Discrete Keywords:	Thermoregulation, heat stress, cellular stressresponse, hyperthermia, thermotolerance, heat shock protein 72, heat illness
Subjects:	Q Science > QP Physiology
Divisions:	College of Business, Psychology and Sport > School of Sport and Exercise Science
Related URLs:	Publisher http://library.worc.ac.uk/
Depositing User:	Jessica Mee
Date Deposited:	06 Jun 2019 13:23
Last Modified:	12 Oct 2020 11:06
URI:	https://eprints.worc.ac.uk/id/eprint/8124

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