Di Miceli, Mathieu ORCID: https://orcid.org/0000-0003-3713-0370, Omoloye, A. and Gronier, B.
(2019)
Chronic methylphenidate treatment during adolescence has long-term effects on monoaminergic function.
Journal of Psychopharmacology, 33 (1).
pp. 109-121.
ISSN Print: 0269-8811 Online: 1461-7285
![]() |
Text
Di Miceli Omoloye Gronier 2018 - Chronic methylphenidate treatment during adolescence has long-term effects on monoaminergic functions - Psychopharmacology.pdf - Published Version Restricted to Repository staff only Download (1MB) | Request a copy |
Abstract
BACKGROUND
Psychostimulants like methylphenidate or D-amphetamine are often prescribed for attention deficit and hyperactivity disorders in children. Whether such drugs can be administered into a developing brain without consequences in adulthood is still an open question.
METHODS
Here, using in vivo extracellular electrophysiology in anesthetised preparations, combined with behavioural assays, we have examined the long-term consequences in adulthood of a chronic methylphenidate oral administration (5 mg/kg/day, 15 days) in early adolescent (post-natal day 28) and late adolescent (post-natal day 42) rats, by evaluating body weight change, sucrose preference (indicator of anhedonia), locomotor sensitivity to D-amphetamine and electrical activities of ventral tegmental area dopamine and dorsal raphe nucleus serotonin neurons.
RESULTS
Chronic methylphenidate treatment during early or late adolescence did not induce weight deficiencies and anhedonia-like behaviours at adulthood. However, it increased bursting activities of dorsal raphe nucleus serotonin neurons. Furthermore, chronic methylphenidate treatment during early but not during late adolescence enhanced D-amphetamine-induced rearing activity, as well as ventral tegmental area dopamine cell excitability (firing, burst and population activity), associated with a partial desensitisation of dopamine D auto-receptors.
CONCLUSIONS
We have demonstrated here that early, but not late, adolescent exposure to oral methylphenidate may induce long-lasting effects on monoamine neurotransmission. The possible clinical implication of these data will be discussed.
Item Type: | Article |
---|---|
Additional Information: | Staff and students at the University of Worcester can access the full-text of the online published article via the online Library Search. External users should check availability with their local library or Interlibrary Requests Service. |
Uncontrolled Discrete Keywords: | methylphenidate, adolescence, dopamine neurons, serotonin neurons, electrophysiology |
Divisions: | College of Health, Life and Environmental Sciences > School of Science and the Environment |
Related URLs: | |
Depositing User: | Mathieu Di Miceli |
Date Deposited: | 06 Oct 2021 11:17 |
Last Modified: | 07 Dec 2021 16:52 |
URI: | https://eprints.worc.ac.uk/id/eprint/11402 |
Actions (login required)
![]() |
View Item |