Pisani, L.P., Oller do Nascimento, C.M., Bueno, Allain ORCID: https://orcid.org/0000-0002-9456-8558, Biz, C., Albuquerque, K.T., Ribeiro, E.B. and Oyama, L.M. (2008) Hydrogenated Fat Diet Intake during Pregnancy and Lactation Modifies the PAI-1 Gene Expression in White Adipose Tissue of Offspring in Adult Life. Lipids in Health and Disease, 7 (13). ISSN 1476-511X
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Hydrogenated fat diet intake during pregnancy and lactation modifies the PAI-1 gene expression in white adipose tissue of offspring in adult life.pdf - Published Version Available under License Creative Commons Attribution. Download (354kB) | Preview |
Abstract
We examine whether feeding pregnant and lactating rats hydrogenated fats rich in trans fatty acids modifies the plasma lipid profiles and the expression of adipokines involved with insulin resistance and cardiovascular disease in their 90-day-old offspring. Pregnant and lactating Wistar rats were fed with either a control diet (C group) or one enriched with hydrogenated vegetable fat (T group). Upon weaning, the male pups were sorted into four groups: CC, mothers were receiving C and pups were kept on C; CT, mothers were receiving C and pups were fed with T; TT, mothers were receiving T and pups were kept on T; TC, mothers were receiving T and pups were fed with C. Pups' food intake and body weight were quantified weekly and the pups were killed at day 90 of life by decapitation. Blood and carcass as well as retroperitoneal, epididymal, and subcutaneous white adipose tissues were collected. Food intake and body weight were lower in TC and TT, and metabolic efficiency was reduced in TT. Offspring of TT and TC rats had increased white adipose tissue PAI-1 gene expression. Insulin receptor was higher in TT than other groups. Ingestion of hydrogenated vegetable fat by the mother during gestation and lactation could promote deleterious consequences, even after the withdrawal of the causal factor.
Item Type: | Article |
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Additional Information: | This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Uncontrolled Discrete Keywords: | pregnancy, fatty acids, lipids, lactation, White Adipose Tissue |
Subjects: | Q Science > Q Science (General) Q Science > QP Physiology R Medicine > RG Gynecology and obstetrics R Medicine > RM Therapeutics. Pharmacology |
Divisions: | College of Health, Life and Environmental Sciences > School of Science and the Environment |
Related URLs: | |
Copyright Info: | Open Access journal |
Depositing User: | Tanya Buchanan |
Date Deposited: | 09 Aug 2016 13:14 |
Last Modified: | 17 Jun 2020 17:12 |
URI: | https://eprints.worc.ac.uk/id/eprint/4764 |
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