University of Worcester Worcester Research and Publications

Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae)

Makong, Y.S., Mouthé Happi, G. ORCID:, Djouaka Bavoua, J.L., Wansi, J.D. ORCID:, Nahar, L., Kamdem Waffo, A.F., Martin, Claire ORCID:, Sewald, N. ORCID: and Sarker, S.D. ORCID: (2019) Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae). Molecules, 24 (23). e4412. ISSN 1420-3049

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A phytochemical study of the root and bark of Brucea antidysenterica J. F. Mill. (Simaroubaceae) afforded three new compounds, including a stilbene glycoside bruceanoside A (1), and two canthinone alkaloids bruceacanthinones A (3) and B (4), along with ten known secondary metabolites, rhaponticin (2), 1,11-dimethoxycanthin-6-one (5), canthin-6-one (6), 1-methoxycanthin-6-one (7), 2-methoxycanthin-6-one (8), 2-hydroxy-1,11-dimethoxycanthin-6-one (9), β-carboline-1-propionic acid (10), cleomiscosin C (11), cleomiscosin A (12), and hydnocarpin (13). The structures of all the compounds were determined using spectrometric and spectroscopic methods including 1D and 2D NMR, and HRSEIMS. The identities of the known compounds were further confirmed by comparison of their data with those reported in the literature. The root and bark methanolic extracts, the dichloromethane and ethyl acetate soluble fractions, and the isolated compounds (3−13), were assessed for their cytotoxicity against the cancer cell lines A-549, MCF-7, and PC-3. The results suggested that compounds in the extracts might possess a synergic action in their cytotoxicity.

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© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (

Uncontrolled Discrete Keywords: Brucea antidysenterica, Simaroubaceae, bruceanoside A, bruceacanthinones A–B, cytotoxicity
Divisions: College of Health, Life and Environmental Sciences > School of Science and the Environment
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Copyright Info: Open Access journal
SWORD Depositor: Prof. Pub Router
Depositing User: Claire Martin
Date Deposited: 09 Dec 2019 13:18
Last Modified: 17 Jun 2020 17:33

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