University of Worcester Worcester Research and Publications
 
  USER PANEL:
  ABOUT THE COLLECTION:
  CONTACT DETAILS:

Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae)

Makong, Y.S., Mouthé Happi, G. ORCID: https://orcid.org/0000-0001-9659-6125, Djouaka Bavoua, J.L., Wansi, J.D. ORCID: https://orcid.org/0000-0002-5111-4361, Nahar, L., Kamdem Waffo, A.F., Martin, Claire, Sewald, N. ORCID: https://orcid.org/0000-0002-0309-2655 and Sarker, S.D. ORCID: https://orcid.org/0000-0003-4038-0514 (2019) Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae). Molecules, 24 (23). e4412. ISSN 1420-3049

[img]
Preview
Text
Martin-Claire-Cytotoxic-Stilbenes.pdf - Published Version
Available under License Creative Commons Attribution.

Download (875kB) | Preview

Abstract

A phytochemical study of the root and bark of Brucea antidysenterica J. F. Mill. (Simaroubaceae) afforded three new compounds, including a stilbene glycoside bruceanoside A (1), and two canthinone alkaloids bruceacanthinones A (3) and B (4), along with ten known secondary metabolites, rhaponticin (2), 1,11-dimethoxycanthin-6-one (5), canthin-6-one (6), 1-methoxycanthin-6-one (7), 2-methoxycanthin-6-one (8), 2-hydroxy-1,11-dimethoxycanthin-6-one (9), β-carboline-1-propionic acid (10), cleomiscosin C (11), cleomiscosin A (12), and hydnocarpin (13). The structures of all the compounds were determined using spectrometric and spectroscopic methods including 1D and 2D NMR, and HRSEIMS. The identities of the known compounds were further confirmed by comparison of their data with those reported in the literature. The root and bark methanolic extracts, the dichloromethane and ethyl acetate soluble fractions, and the isolated compounds (3−13), were assessed for their cytotoxicity against the cancer cell lines A-549, MCF-7, and PC-3. The results suggested that compounds in the extracts might possess a synergic action in their cytotoxicity.

Item Type: Article
Additional Information:

The full-text of the online published article can be accessed via the official URL.

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Uncontrolled Keywords: Brucea antidysenterica, Simaroubaceae, bruceanoside A, bruceacanthinones A–B, cytotoxicity
Divisions: College of Health, Life and Environmental Sciences > School of Science and the Environment
Related URLs:
Copyright Info: Open Access journal
SWORD Depositor: Prof. Pub Router
Depositing User: Claire Martin
Date Deposited: 09 Dec 2019 13:18
Last Modified: 09 Dec 2019 13:18
URI: https://eprints.worc.ac.uk/id/eprint/8970

Actions (login required)

View Item View Item
 
     
Worcester Research and Publications is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.