Makong, Y.S., Mouthé Happi, G. ORCID: https://orcid.org/0000-0001-9659-6125, Djouaka Bavoua, J.L., Wansi, J.D.
ORCID: https://orcid.org/0000-0002-5111-4361, Nahar, L., Kamdem Waffo, A.F., Martin, Claire
ORCID: https://orcid.org/0000-0002-5497-4594, Sewald, N.
ORCID: https://orcid.org/0000-0002-0309-2655 and Sarker, S.D.
ORCID: https://orcid.org/0000-0003-4038-0514
(2019)
Cytotoxic Stilbenes and Canthinone Alkaloids from Brucea antidysenterica (Simaroubaceae).
Molecules, 24 (23).
e4412.
ISSN 1420-3049
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Text
Martin-Claire-Cytotoxic-Stilbenes.pdf - Published Version Available under License Creative Commons Attribution. Download (875kB) | Preview |
Abstract
A phytochemical study of the root and bark of Brucea antidysenterica J. F. Mill. (Simaroubaceae) afforded three new compounds, including a stilbene glycoside bruceanoside A (1), and two canthinone alkaloids bruceacanthinones A (3) and B (4), along with ten known secondary metabolites, rhaponticin (2), 1,11-dimethoxycanthin-6-one (5), canthin-6-one (6), 1-methoxycanthin-6-one (7), 2-methoxycanthin-6-one (8), 2-hydroxy-1,11-dimethoxycanthin-6-one (9), β-carboline-1-propionic acid (10), cleomiscosin C (11), cleomiscosin A (12), and hydnocarpin (13). The structures of all the compounds were determined using spectrometric and spectroscopic methods including 1D and 2D NMR, and HRSEIMS. The identities of the known compounds were further confirmed by comparison of their data with those reported in the literature. The root and bark methanolic extracts, the dichloromethane and ethyl acetate soluble fractions, and the isolated compounds (3−13), were assessed for their cytotoxicity against the cancer cell lines A-549, MCF-7, and PC-3. The results suggested that compounds in the extracts might possess a synergic action in their cytotoxicity.
Item Type: | Article |
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Additional Information: | The full-text of the online published article can be accessed via the official URL. © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
Uncontrolled Discrete Keywords: | Brucea antidysenterica, Simaroubaceae, bruceanoside A, bruceacanthinones A–B, cytotoxicity |
Divisions: | College of Health, Life and Environmental Sciences > School of Science and the Environment |
Related URLs: | |
Copyright Info: | Open Access journal |
SWORD Depositor: | Prof. Pub Router |
Depositing User: | Claire Martin |
Date Deposited: | 09 Dec 2019 13:18 |
Last Modified: | 17 Jun 2020 17:33 |
URI: | https://eprints.worc.ac.uk/id/eprint/8970 |
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