University of Worcester Worcester Research and Publications

Detection and Seroprevalence of Morbillivirus and Other Paramyxoviruses in Geriatric Cats with and without Evidence of Azotemic Chronic Kidney Disease

McCallum, K.E., Stubbs, S., Hope, N., Mickleburgh, I., Dight, Dave, Tiley, L. and Williams, T.L. (2018) Detection and Seroprevalence of Morbillivirus and Other Paramyxoviruses in Geriatric Cats with and without Evidence of Azotemic Chronic Kidney Disease. Journal of Veterinary Internal Medicine. ISSN 0891-6640 Online: 1939-1676

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Feline morbillivirus (FeMV) is associated with the presence of tubulo-interstitial nephritis (TIN) in cats, however the seroprevalence of FeMV in the UK and the association between the presence of FeMV and renal azotemia is unknown HYPOTHESIS/OBJECTIVES: To identify whether paramyxoviruses are present in urine samples of geriatric cats and to develop an assay to assess FeMV seroprevalence. To investigate the relationship between both urinary paramyxovirus (including FeMV) excretion and FeMV seroprevalence and azotemic chronic kidney disease (CKD). Seventy-nine cats (40 for FeMV detection; 72 for seroprevalence). Retrospective cross-sectional, case control study. Viral RNA was extracted from urine for RT-PCR. PCR products were sequenced for virus identification and comparison. The FeMV N protein gene was cloned and partially purified for use as an antigen to screen cat sera for anti-FeMV antibodies by Western Blot. Feline morbillivirus RNA from five distinct morbilliviruses were identified. Detection was not significantly different between azotemic CKD (1/16) and nonazotemic groups (4/24; P = .36). Three distinct, non-FeMV paramyxoviruses were present in the nonazotemic group but their absence from the azotemic group was not statistically significant (P = .15). 6/14 (43%) azotemic cats and 40/55 (73%) nonazotemic cats were seropositive (P = .06). Feline morbillivirus was detected in cats in the UK for the First time. However, there was no association between virus prevalence or seropositivity and azotemic CKD. These data do not support the hypothesis that FeMV infection is associated with the development of azotemic CKD in cats in the UK. [Abstract copyright: © 2018 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.]

Item Type: Article
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Uncontrolled Discrete Keywords: azotemia, feline, morbillivirus, paramyxovirus
Subjects: Q Science > Q Science (General)
Divisions: College of Health, Life and Environmental Sciences > School of Science and the Environment
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SWORD Depositor: Prof. Pub Router
Depositing User: Karol Kosinski
Date Deposited: 12 Apr 2018 11:18
Last Modified: 17 Jun 2020 17:22

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