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Phase-based Treatment Versus Immediate Trauma-focused Treatment in Patients with Childhood Trauma-related Posttraumatic Stress Disorder: Study Protocol for a Randomized Controlled Trial

van Vliet, N.I., Huntjens, R.J., van Dijk, M.K. and de Jongh, Ad (2018) Phase-based Treatment Versus Immediate Trauma-focused Treatment in Patients with Childhood Trauma-related Posttraumatic Stress Disorder: Study Protocol for a Randomized Controlled Trial. Trials, 19. p. 138. ISSN 1745-6215

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Abstract

The treatment of posttraumatic stress disorder (PTSD) related to a history of sexual and/or physical abuse in childhood is the subject of international debate, with some favouring a phase-based approach as their preferred treatment, while others argue for immediate trauma-focused treatment. A history of (chronic) traumatisation during childhood has been linked to the development of distinct symptoms that are often labelled as symptoms of complex PTSD. Many therapists associate the presence of symptoms of complex PTSD with a less favourable treatment prognosis. The purpose of this study is to determine whether a phase-based approach is more effective than stand-alone trauma-focused therapy in individuals with PTSD and possible symptoms of complex PTSD resulting from a history of repeated sexual and/or physical abuse in childhood. An additional aim is to investigate moderators, predictors of treatment (non) response and drop-out. The sample consists of patients between 18 and 65 years old with a diagnosis of PTSD who report a history of repeated sexual and/or physical abuse in childhood (N = 122). Patients will be blindly allocated to either 16 sessions of eye movement desensitization and reprocessing (EMDR) therapy preceded by a stabilization phase (eight sessions of Skills Training in Affect and Interpersonal Regulation (STAIR)) or only 16 sessions of EMDR therapy. Assessments are carried out pre-treatment, after every eighth session, post-treatment, and at 3 and 6 months follow up. The main parameter will be the severity of PTSD symptoms (PTSD Symptoms Scale-Self Report). Secondary outcome variables are the presence of a PTSD diagnosis (Clinician-Administered PTSD Scale for DSM-5), severity of complex PTSD symptoms (Structured Interview for Disorders of Extreme Stress-Revised and symptoms-specific questionnaires), changes in symptoms of general psychopathology (Brief Symptom Inventory), and quality of life (Euroqol-5D). Health care consumption and productivity loss in patients will also be indexed. The study results may help to inform the ongoing debate about whether a phase-based approach has added value over immediate trauma-focused therapy in patients suffering from PTSD due to childhood abuse. Furthermore, the results will contribute to knowledge about the safety, efficacy, and cost-effectiveness of treatments in this target group. Nederlands Trialregister, NTR5991 . Registered on 23 august 2016. http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=5991.

Item Type: Article
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Uncontrolled Keywords: complex PTSD, EMDR, PTSD, STAIR, Trauma-focused therapy, treatment
Subjects: R Medicine > R Medicine (General)
Divisions: Academic Departments > Institute of Health and Society
SWORD Depositor: Prof. Pub Router
Depositing User: Karol Kosinski
Date Deposited: 13 Apr 2018 13:36
Last Modified: 13 Apr 2018 13:36
URI: https://eprints.worc.ac.uk/id/eprint/6462

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