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Can BCAT1 Expression Level Help Predict Disease Progression in Chronic Lymphocytic Leukaemia

Coles, Steven and Wadley, Alex (2017) Can BCAT1 Expression Level Help Predict Disease Progression in Chronic Lymphocytic Leukaemia. Cancer and Oncology: Open Access Journal, 1 (1).

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Abstract

Chronic lymphocytic leukaemia (CLL) is the most common blood cancer in the UK, with an incidence of >3500 newly diagnosed cases per year resulting in >1000 deaths. Disease prevalence increases with age, where the majority of patients are >65 years old [1]. CLL is a largely indolent disease and is routinely staged according to the Binet system as follows; stage A (involving 0-2 lymphoid sites), stage B (involving 2-5 lymphoid cites) and stage C (platelets < 1x1011/L or haemoglobin <10g/dL), the latter stage reflecting loss of bone marrow function [2]. Whilst for some stage A patients, the disease may remain stable for many decades (median life expectancy of 13 years), for others the disease progresses more rapidly [3]. This observation likely reflects the genetic and molecular heterogeneity of CLL. As such there are several prognostic risk factors used to stratify newly diagnosed patients, which include; trisomy-12, 13q/17p/11q23 deletion, advanced stage, males>females, unmutated VH Ig genes, raised lactate dehydrogenase activity and expression of Zap70 and CD38 [4]. CLL is traditionally treated with a combination of chemotherapeutic reagents, namely, Fludarabine/ Cyclophosphamide/Rituximab (FCR), however treatment remains challenging within the elderly population [1]. Lately the Brutan’s tyrosine kinase inhibitor, Ibrutinib, has shown great promise for the treatment of CLL [5]. However, exceptions are identified as well as treatment resistance prompting further research into CLL treatment strategies [6].

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Uncontrolled Keywords: CLL, lymphocyte, prognosis, oncogenesis, metabolism
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Academic Departments > Institute of Science and the Environment
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Depositing User: Steven Coles
Date Deposited: 22 Nov 2017 08:56
Last Modified: 13 Aug 2018 13:58
URI: https://eprints.worc.ac.uk/id/eprint/6118

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