WRaP - Worcester Research and Publications

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Biography

Expertise:

Leukaemia, Cancer, Immunology, Oxidative Stress

Job title:

Senior Lecturer (Biochemistry)

Qualifications:

PhD Biomedical Sciences (Neurochemistry) [UWE, 2005] BSc(Hons) Biochemistry and Molecular Biology [UWE, 2005]

My Latest As Author

Doughty, Angela, Keane, Gary, Wadley, Alex, Mahoney, Berenice ORCID: https://orcid.org/0000-0002-7414-8185, Bueno, Allain ORCID: https://orcid.org/0000-0002-9456-8558 and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2024) Plasma concentrations of thioredoxin, thioredoxin reductase and peroxiredoxin-4 can identify high risk patients and predict outcome in patients with acute coronary syndrome: a clinical observation. International Journal of Cardiology. pp. 1-36. ISSN 0167-5273 (print) 1874-1754 (web)
Joyce, Ellen ORCID: https://orcid.org/0000-0002-2595-2898, Machado, Meira, Hirata, Bruna, Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Cherry, Amy ORCID: https://orcid.org/0000-0002-8222-1071, Telles, Monica and Bueno, Allain ORCID: https://orcid.org/0000-0002-9456-8558 (2023) Ginkgo Biloba supplementation modulates dimethyl acetal levels differently in hypothalamus and hippocampus of diet-induced obese rats. In: IBRO 2023, 9th to 13th September 2023, Granada.
de Carvalho, J.F., Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 and Bueno, Allain ORCID: https://orcid.org/0000-0002-9456-8558 (2023) Vitamin B12 (cobalamin) supplementation for the management of autoimmune rheumatic diseases: potential indications and opportunity for future research. Rheumatology International. ISSN Print: 0172-8172 Online: 1437-160X
Paskin, Samantha, Bueno, Allain ORCID: https://orcid.org/0000-0002-9456-8558, Davis, Sarah K. ORCID: https://orcid.org/0000-0002-4683-4807 and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2023) Relationship between social media exposure, neuropsychological profile and associations with nutritional status and buccal cell fatty acid profile. In: 8th European Congress of Psychology - Psychology: Uniting communities for a sustainable world, 3-6 July 2023, Brighton, UK.
Hillier, James, Brunet, Mathieu, Terry, Rebecca, Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 and Wall, Ivan (2023) The BCAT1 CXXC motif modulates extracellular vesicle release in acute myeloid leukaemia cell line U937. In: International Society for Extracellular Vesicles Annual Meeting, 17th to 21st May 2023, Seattle Convention Centre.
Wadley, A. J. and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2022) Time to ‘Couple’ Redox Biology with Exercise Immunology. In: Oxidative Eustress in Exercise Physiology. Oxidative Stress and Disease . CRC Press, Abingdon, pp. 85-94. ISBN 9780367508760; eBook: 9781003051619
Hillier, James, Allcott, Gemma, Guest, Laura, Heaselgrave, Wayne, Tonks, Alex, Conway, Myra, Cherry, Amy ORCID: https://orcid.org/0000-0002-8222-1071 and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2022) The BCAT1 CXXC Motif Provides Protection Against ROS in Acute Myeloid Leukaemia Cells. Antioxidants, 11 (4). p. 683. ISSN 2076-3921
Rastogi, N., Baker, S., Man, S., Uger, R., Wong, M., Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Hodges, M., Gilkes, A., Knapper, S., Darley, R. and Tonks, A. (2021) Use of an anti-CD200 blocking antibody improves immune responses to AML in vitro and in vivo. British Journal of Haematology, 193 (1). pp. 155-159. ISSN 1365-2141
Wilde, Emma, Cramp, S., Wright, M., Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 and Cherry, Amy ORCID: https://orcid.org/0000-0002-8222-1071 (2020) Crosstalk Between Myeloid Leukaemia Factors and Hedgehog Signalling Highlights the Potential for New Treatment Strategies for Leukaemia. In: EuroLeuk 2020, 29-30 October 2020, Online. (Unpublished)
Hillier, James, Heaselgrave, Wayne and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2020) BCAT1 increases sensitivity to Cytarabine and confers CXXC motif derived resistance to pro-oxidant treatment in Acute Myeloid Leukaemiacells. In: British Society for Haematology Annual Scientific Meeting, 26-29th April 2020, Birmingham. ISSN 1365-2141 (Unpublished)
Wadley, Alex, Cullen, Tom, Vautrinot, Jordan, Keane, Gary, Bishop, N.C. and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2020) High intensity interval exercise increases the frequency of peripheral PD-1+ CD8+ central memory T-cells and soluble PD-L1 in humans. Brain Behaviour and Immunity: Health, 3. Article no. 100049. ISSN 2666-3546
Heaselgrave, W., Hamad, A., Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 and Hau, S. (2019) In Vitro Evaluation of the Inhibitory Effect of Topical Ophthalmic Agents on Acanthamoeba Viability. Translational Vision Science and Technology, 8 (5). Article no. 17. ISSN 2164-2591
Wadley, A., Keane, Gary, Cullen, Tom, James, L., Vautrinot, Jordon, Davies, Matthew, Hussey, B., Hunter, D.J., Mastana, S., Holliday, A., Petersen, SV., Bishop, N.C., Lindley, M.R. and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2019) Characterisation of Extracellular Redox Enzyme Concentrations in Response to Exercise in Humans. Journal of Applied Physiology, 127 (3). pp. 858-866. ISSN Print: 8750-7587 Online: 1522-1601
Wadley, A., Morgan, R.G., Darley, R.L., Hole, P.S. and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2019) Using Flow Cytometry to Detect and Measure Intracellular Thiol Redox Status in Viable T Cells from Heterogeneous Populations. In: Redox-Mediated Signal Transduction: Methods and Protocols (2nd Edition). Methods in Molecular Biology . Springer US (Humana Press), New York, NY, pp. 53-70. ISBN Print: 978-1-4939-9461-8 Online: 978-1-4939-9463-2
Wadley, A.J., Hole, P., Tonks, A., Darley, R., Omidvar, D., Morgan, R., Gary, Keane and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2018) Intracellular Thiol Oxidation Is Linked with Loss of Δψm and Disease Progression in Acute Promyelocytic Leukaemia. Blood, 132. p. 2751. ISSN 00064971
Hillier, James, Wadley, A.J., Morgan, R.G., Cherry, Amy ORCID: https://orcid.org/0000-0002-8222-1071, Conway, M.E. and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2018) Identification and Characterisation of a Novel Antioxidant Activity for the BCAT1 Cxxc Motif: Implications for Myeloid Leukaemia Development. Blood, 132. p. 1473. ISSN 00064971
Wadley, Alex, Morgan, R.G., Heesom, K.J., Hole, P.S. and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2018) Detecting Intracellular Thiol Redox State in Leukaemia and Heterogeneous Immune Cell Populations: an Optimised Protocol for Digital Flow Cytometers. MethodsX, 5. pp. 1473-1483. ISSN 2215-0161
Hillier, James, Wadley, A., Morgan, R., Cherry, Amy ORCID: https://orcid.org/0000-0002-8222-1071, Conway, M.E. and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2018) Identification and Characterisation of a Novel Antioxidant Activity for the BCAT1 Cxxc Motif: Implications for Myeloid Leukaemia Development. In: 60th ASH Annual Meeting & Exposition, 1st - 4th December 2018, San Diego Convention Center, CA, USA. (Unpublished)
Wadley, A., Hole, P., Tonks, A., Darley, R.L., Omidvar, N., Morgan, R., Keane, Gary and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2018) Intracellular Thiol Oxidation Is Linked with Loss of Δψm and Disease Progression in Acute Promyelocytic Leukaemia. In: 60th ASH Annual Meeting & Exposition, 1st - 4th December 2018, San Diego Convention Center, CA, USA. (Unpublished)
Wadley, Alex, Holliday, Adrian, Morgan, R.G., Heesom, K.J., Aldred, S., Peters, D.M. ORCID: https://orcid.org/0000-0002-7873-7737, Bueno, Allain ORCID: https://orcid.org/0000-0002-9456-8558 and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2018) Preliminary Evidence of Reductive Stress in Human Cytotoxic T-cells Following Exercise. Journal of Applied Physiology, 125 (2). pp. 586-595. ISSN 8750-7587 Online: 1522-1601
Morgan, R.G., Chambers, A., Legge, D.N., Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Greenhough, A. and Williams, A.C. (2018) Optimized Delivery of siRNA Into 3D Tumor Spheroid Cultures in Situ. Scientific Reports, 8 (7952). ISSN 2045-2322
Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2018) Targeting the Immune Checkpoint in Cancer: Is This a Viable Treatment Option for AML? Open Access Journal of Oncology and Medicine, 1 (2). pp. 1-2. ISSN 2638-5945
Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 and Wadley, Alex (2017) Can BCAT1 Expression Level Help Predict Disease Progression in Chronic Lymphocytic Leukaemia. Cancer and Oncology: Open Access Journal, 1 (1).
Wadley, Alex, Aldred, S. and Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 (2016) Mini Review: An Unexplored Role for Peroxiredoxin in Exercise-induced Redox Signalling? Redox Biology, 8. pp. 51-58. ISSN Print: 2213-2317 Online: 2213-2317
Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Gilmour, M.N., Reed, R., Knapper, S., Burnett, A.K., Man, S., Tonks, A. and Darley, R.L. (2015) The Immunosuppressive Ligands PD-L1 and CD200 are Linked in AML T-cell Immunosuppression: Identification of a New Immunotherapeutic Synapse. Leukemia, 29 (9). pp. 1952-1954. ISSN Print: 0887-6924 Online: 1476-5551
Agathanggelou, A., Weston, V.J., Perry, T., Davies, N.J., Skowronska, A., Payne, D.T., Fossey, J.S., Oldreive, C.E., Wei, W., Pratt, G., Parry, H., Oscier, D., Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Hole, P.S., Darley, R.L., McMahon, M., Hayes, J.D., Moss, P., Stewart, G., Taylor, M. and Stankovic, T. (2015) Targeting the Ataxia Telangiectasia Mutated-null Phenotype in Chronic Lymphocytic Leukemia with Pro-oxidants. Haematologica, 100 (8). pp. 1076-1085. ISSN Print: 0390-6078 Online: 1592-8721
Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Gilmour, M.N., Reid, R., Knapper, S., Burnett, A.K., Man, S., Tonks, A. and Darley, R.L. (2014) CD200 and PD1-L1 in AML Are Associated with Expanded PD-1+ Late Differentiated CD8+ T Cells and a Decreased CD4:CD8 Ratio: a New Link Between Distinct Immunosuppressive Pathways. In: 56th American Society of Hematology Annual Meeting and Exposition, 6th - 9th December 2014, San Francisco. (Unpublished)
Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Hills, R.K., Wang, E.C.Y., Burnett, A.K., Man, S., Darley, R.L. and Tonks, A. (2012) Expression of CD200 on AML Blasts Directly Suppresses Memory T-cell Function. Leukemia, 26 (9). pp. 2148-2151. ISSN Print: 0887-6924 Online: 1476-5551
Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Hills, R.K., Wang, E.C.Y., Burnett, A.K., Man, S., Darley, R.L. and Tonks, A. (2012) Increased CD200 Expression in Acute Myeloid Leukemia is Linked With an Increased Frequency of FoxP3+ Regulatory T Cells. Leukemia, 26 (9). pp. 2146-2148. ISSN Print: 0887-6924 Online: 1476-5551
Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Hancock, J.T. and Conway, M.E. (2012) Differential Redox Potential Between the Human Cytosolic and Mitochondrial Branched-chain Aminotransferase. Acta Biochimica et Biophysica Sinica, 44 (2). pp. 172-176. ISSN Print: 1672-9145 Online: 1745-7270
Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Man, S., Hills, R.K., Wang, E.C.Y., Burnett, A.K., Darley, R.L. and Tonks, A. (2011) CD200 Inhibits Memory Th1 Cell Function in Acute Myeloid Leukaemia (AML). In: Annual Congress of the British Society for Immunology, 5th - 8th December 2011, Liverpool, UK. (Unpublished)
Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Wang, E.C.Y., Man, S., Hills, R.K., Burnett, A.K., Tonks, A. and Darley, R.L. (2011) CD200 Expression Suppresses Natural Killer Cell Function and Directly Inhibits Patient Anti-tumor Response in Acute Myeloid Leukemia. Leukemia, 25 (5). pp. 792-799. ISSN Print: 0887-6924 Online: 1476-5551
Walsby, E.J., Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Knapper, S. and Burnett, A.K. (2011) The Topoisomerase II Inhibitor Voreloxin Causes Cell Cycle Arrest and Apoptosis in Myeloid Leukemia Cells and Acts in Synergy with Cytarabine. Haematologica, 96 (3). pp. 393-399. ISSN Print: 0390-6078 Online: 1592-8721
Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Man, S., Hills, R., Wang, E.C.Y., Burnett, A.K., Darley, R.L. and Tonks, A. (2010) Over-expression of CD200 in Acute Myeloid Leukemia Mediates the Expansion of Regulatory T-lymphocytes and Directly Inhibits Natural Killer Cell Tumor Immunity. In: 52nd American Society of Hematology Annual Meeting and Exposition, 4th - 7th December 2010, Orlando, Florida.
Walsby, E.J., Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Knapper, S., Pepper, C. and Burnett, A.K. (2009) Topoisomerase II Inhibitor Voreloxin Causes Cell Cycle Arrest and Apoptosis in Acute Myeloid Leukaemia Cells and Acts in Synergy with Cytarabine. In: 51st American Society of Hematology (ASH) Annual Meeting and Exposition, 5th - 8th December 2009, New Orleans, LA, USA. (Unpublished)
Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Man, S., Wang, E., Burnett, A.K., Darley, R.L. and Tonks, A. (2009) The role of CD200 in AML tumour immunity. In: RUNX Transcription Factors in Development and Disease Annual Meeting, 16-19 August, 2009, Oxford. (Unpublished)
Hutson, S.M., Poole, L.B., Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971 and Conway, M.E. (2009) Redox Regulation and Trapping Sulphenic Acid in the Peroxide Sensitive Human Mitochondrial Branched Chain Aminotransferase. In: Redox-Mediated Signal Transduction: Methods and Protocols. Methods in Molecular Biology . Humana Press, New York, pp. 135-148. ISBN Hardback: 978-1-58829-842-3 Paperback: 978-1-61737-802-7
Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Easton, P., Sharrod, H., Hutson, S.M., Hancock, J.T., Patel, V.B. and Conway, M.E. (2009) S-Nitrosoglutathione Inactivation of the Mitochondrial and Cytosolic BCAT Proteins: S-nitrosation and S-thiolation. Biochemistry, 48 (3). pp. 645-656. ISSN Print: 0006-2960 Online: 1520-4995
Conway, M.E., Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Islam, M.M. and Hutson, S.M. (2008) Regulatory Control of Human Cytosolic Branched-chain Aminotransferase by Oxidation and S-glutathionylation and its Interactions with Redox Sensitive Neuronal Proteins. Biochemistry, 47 (19). pp. 5465-5479. ISSN Print: 0006-2960 Online: 1520-4995
Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Hancock, J.T., Hutson, S.M. and Conway, M.E. (2007) S-nitrosylation of the human branched chain aminotransferase isoenzymes. In: 7th United Kingdom Nitric Oxide Forum, 2007, Bradford. (Unpublished)
Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Hutson, S.M., Hancock, J.T. and Conway, M.E. (2006) S-nitrosylation, redox regulation and the human branched chain aminotransferase (hBCATc). In: Centennial Meeting of the Biochemical Society, 23-27 July, 2006, Glasgow. (Unpublished)
Conway, M.E., Coles, Steven ORCID: https://orcid.org/0000-0002-1109-6971, Islam, M., Mallet, C. and Hutson, S.M. (2006) The human branched chain aminotransferase (hBCATc) differs in sensitivity to peroxide compared to the mitochondrial isofrom. In: Biochemical Society Annual Meeting, 2006. (Unpublished)

My Most Viewed As Author

#	Item title
1.	Intracellular Thiol Oxidation Is Linked with Loss of Δψm and Disease Progression in Acute Promyelocytic Leukaemia	857	3
2.	Characterisation of Extracellular Redox Enzyme Concentrations in Response to Exercise in Humans	335	62
3.	Can BCAT1 Expression Level Help Predict Disease Progression in Chronic Lymphocytic Leukaemia	324	186
4.	Targeting the Immune Checkpoint in Cancer: Is This a Viable Treatment Option for AML?	304	77
5.	Detecting Intracellular Thiol Redox State in Leukaemia and Heterogeneous Immune Cell Populations: an Optimised Protocol for Digital Flow Cytometers	276	58
6.	In Vitro Evaluation of the Inhibitory Effect of Topical Ophthalmic Agents on Acanthamoeba Viability	274	205
7.	The BCAT1 CXXC Motif Provides Protection Against ROS in Acute Myeloid Leukaemia Cells	264	95
8.	BCAT1 increases sensitivity to Cytarabine and confers CXXC motif derived resistance to pro-oxidant treatment in Acute Myeloid Leukaemiacells	256	1
9.	Preliminary Evidence of Reductive Stress in Human Cytotoxic T-cells Following Exercise	249	83
10.	Optimized Delivery of siRNA Into 3D Tumor Spheroid Cultures in Situ	230	140
11.	Mini Review: An Unexplored Role for Peroxiredoxin in Exercise-induced Redox Signalling?	224	53
12.	Identification and Characterisation of a Novel Antioxidant Activity for the BCAT1 Cxxc Motif: Implications for Myeloid Leukaemia Development	217	2
13.	Use of an anti-CD200 blocking antibody improves immune responses to AML in vitro and in vivo	216	109
14.	The Immunosuppressive Ligands PD-L1 and CD200 are Linked in AML T-cell Immunosuppression: Identification of a New Immunotherapeutic Synapse	211	214
15.	CD200 Inhibits Memory Th1 Cell Function in Acute Myeloid Leukaemia (AML)	210
16.	Targeting the Ataxia Telangiectasia Mutated-null Phenotype in Chronic Lymphocytic Leukemia with Pro-oxidants	196	48
17.	CD200 Expression Suppresses Natural Killer Cell Function and Directly Inhibits Patient Anti-tumor Response in Acute Myeloid Leukemia	193
18.	S-Nitrosoglutathione Inactivation of the Mitochondrial and Cytosolic BCAT Proteins: S-nitrosation and S-thiolation	187
19.	Topoisomerase II Inhibitor Voreloxin Causes Cell Cycle Arrest and Apoptosis in Acute Myeloid Leukaemia Cells and Acts in Synergy with Cytarabine	186
20.	High intensity interval exercise increases the frequency of peripheral PD-1+ CD8+ central memory T-cells and soluble PD-L1 in humans	183	77
21.	CD200 and PD1-L1 in AML Are Associated with Expanded PD-1+ Late Differentiated CD8+ T Cells and a Decreased CD4:CD8 Ratio: a New Link Between Distinct Immunosuppressive Pathways	179
22.	Crosstalk Between Myeloid Leukaemia Factors and Hedgehog Signalling Highlights the Potential for New Treatment Strategies for Leukaemia	177
23.	The BCAT1 CXXC motif modulates extracellular vesicle release in acute myeloid leukaemia cell line U937	170
24.	Expression of CD200 on AML Blasts Directly Suppresses Memory T-cell Function	167
25.	Regulatory Control of Human Cytosolic Branched-chain Aminotransferase by Oxidation and S-glutathionylation and its Interactions with Redox Sensitive Neuronal Proteins	166
26.	Time to ‘Couple’ Redox Biology with Exercise Immunology	165	77
27.	Over-expression of CD200 in Acute Myeloid Leukemia Mediates the Expansion of Regulatory T-lymphocytes and Directly Inhibits Natural Killer Cell Tumor Immunity	161
28.	The Topoisomerase II Inhibitor Voreloxin Causes Cell Cycle Arrest and Apoptosis in Myeloid Leukemia Cells and Acts in Synergy with Cytarabine	160
29.	S-nitrosylation of the human branched chain aminotransferase isoenzymes	156
30.	Differential Redox Potential Between the Human Cytosolic and Mitochondrial Branched-chain Aminotransferase	156
31.	Vitamin B12 (cobalamin) supplementation for the management of autoimmune rheumatic diseases: potential indications and opportunity for future research	149
32.	Intracellular Thiol Oxidation Is Linked with Loss of Δψm and Disease Progression in Acute Promyelocytic Leukaemia	149
33.	Plasma concentrations of thioredoxin, thioredoxin reductase and peroxiredoxin-4 can identify high risk patients and predict outcome in patients with acute coronary syndrome: a clinical observation	147	26
34.	The human branched chain aminotransferase (hBCATc) differs in sensitivity to peroxide compared to the mitochondrial isofrom	144
35.	Using Flow Cytometry to Detect and Measure Intracellular Thiol Redox Status in Viable T Cells from Heterogeneous Populations	143
36.	Identification and Characterisation of a Novel Antioxidant Activity for the BCAT1 Cxxc Motif: Implications for Myeloid Leukaemia Development	141
37.	Increased CD200 Expression in Acute Myeloid Leukemia is Linked With an Increased Frequency of FoxP3+ Regulatory T Cells	135
38.	Redox Regulation and Trapping Sulphenic Acid in the Peroxide Sensitive Human Mitochondrial Branched Chain Aminotransferase	134
39.	Relationship between social media exposure, neuropsychological profile and associations with nutritional status and buccal cell fatty acid profile	129
40.	Ginkgo Biloba supplementation modulates dimethyl acetal levels differently in hypothalamus and hippocampus of diet-induced obese rats	126
41.	S-nitrosylation, redox regulation and the human branched chain aminotransferase (hBCATc)	117
42.	The role of CD200 in AML tumour immunity	92

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Steven Coles