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The Immunosuppressive Ligands PD-L1 and CD200 are Linked in AML T-cell Immunosuppression: Identification of a New Immunotherapeutic Synapse

Coles, Steven and Gilmour, M.N. and Reed, R. and Knapper, S. and Burnett, A.K. and Man, S. and Tonks, A. and Darley, R.L. (2015) The Immunosuppressive Ligands PD-L1 and CD200 are Linked in AML T-cell Immunosuppression: Identification of a New Immunotherapeutic Synapse. Leukemia, 29 (9). pp. 1952-1954. ISSN Print: 0887-6924 Online: 1476-5551

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Abstract

Long-term remission in acute myeloid leukemia (AML) is generally not durable only being achieved in <50% of patients. Consequently there is a need to establish new treatments to prevent relapse. A promising approach is to augment the anti-tumor immune response in these patients; however, it is well established that overexpression of immunosuppressive molecules such as CD200 on the surface of AML cells directly suppresses the antitumor response. Nevertheless, blocking CD200:CD200R, only partially restores T-cell activity, suggesting that alternative immunosuppressive mechanisms need to be explored if the antitumor response in AML is to be optimally exploited.

Item Type: Article
Uncontrolled Keywords: AML, long-term remission, treatments, acute myeloid leukemia, AML T-cell Immunosuppression, immunosuppressive mechanisms
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Academic Departments > Institute of Science and the Environment
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Depositing User: Steven Coles
Date Deposited: 13 Sep 2017 13:15
Last Modified: 14 Sep 2017 10:46
URI: https://eprints.worc.ac.uk/id/eprint/5870

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