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The Immunosuppressive Ligands PD-L1 and CD200 are Linked in AML T-cell Immunosuppression: Identification of a New Immunotherapeutic Synapse

Coles, Steven, Gilmour, M.N., Reed, R., Knapper, S., Burnett, A.K., Man, S., Tonks, A. and Darley, R.L. (2015) The Immunosuppressive Ligands PD-L1 and CD200 are Linked in AML T-cell Immunosuppression: Identification of a New Immunotherapeutic Synapse. Leukemia, 29 (9). pp. 1952-1954. ISSN Print: 0887-6924 Online: 1476-5551

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Abstract

Long-term remission in acute myeloid leukemia (AML) is generally not durable only being achieved in <50% of patients. Consequently there is a need to establish new treatments to prevent relapse. A promising approach is to augment the anti-tumor immune response in these patients; however, it is well established that overexpression of immunosuppressive molecules such as CD200 on the surface of AML cells directly suppresses the antitumor response. Nevertheless, blocking CD200:CD200R, only partially restores T-cell activity, suggesting that alternative immunosuppressive mechanisms need to be explored if the antitumor response in AML is to be optimally exploited.

Item Type: Article
Uncontrolled Keywords: AML, long-term remission, treatments, acute myeloid leukemia, AML T-cell Immunosuppression, immunosuppressive mechanisms
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Academic Departments > Institute of Science and the Environment
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Depositing User: Steven Coles
Date Deposited: 13 Sep 2017 13:15
Last Modified: 14 Sep 2017 10:46
URI: https://eprints.worc.ac.uk/id/eprint/5870

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