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An Explanatory Randomised Controlled Trial Testing the Effects of Improving Sleep on Mental Health: An Interventionist-causal Model Approach With Mediation Analysis

Freeman, D. and Sheaves, B. and Goodwin, G. and Yu, L. and Nickless, A. and Harrison, P. and Emsley, R. and Luik, A. and Foster, R. and Wadekar, V. and Hinds, C. and Gumley, A. and Jones, R. and Lightman, S. and Jones, S. and Bentall, R. and Kinderman, P. and Rowse, G. and Brugha, T. and Blagrove, M. and Gregory, A. and Fleming, L. and Walklet, Elaine and Glazebrook, C. and Davies, B. and Hollis, C. and Haddock, G. and John, B. and Coulson, M. and Fowler, D. and Pugh, K. and Cape, J. and Moseley, P. and Brown, G. and Hughes, C. and Obonsawin, M. and Coker, S. and Watkins, E. and Schwannauer, M. and Macmahon, K. and Siriwardena, N. and Espie, C. (2017) An Explanatory Randomised Controlled Trial Testing the Effects of Improving Sleep on Mental Health: An Interventionist-causal Model Approach With Mediation Analysis. The Lancet Psychiatry. ISSN 2215-0366 Online: 2215-0374 (In Press)

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Abstract

Background: Sleep difficulties may be a contributory causal factor in the occurrence of mental health problems. If this is true, improving sleep should benefit psychological health. Our primary objective was to determine whether treating insomnia leads to a reduction in paranoia and hallucinations. The effects on other mental health outcomes were also tested. Methods: For our parallel group, single blinded, explanatory randomised controlled trial (called OASIS), we randomised university students with insomnia to digital cognitive behaviour therapy for insomnia or usual practice. Online assessments were at 0, 3, 10 (post-treatment), and 22 weeks. The primary outcomes were insomnia, paranoia, and hallucinatory experiences. The secondary outcomes included anxiety, depression, nightmares, and psychological well-being. The trial was registered (ISRCTN61272251). Findings: 3,755 people were randomised between 5th March 2015 to 17th February 2016. Compared to usual practice, the sleep intervention at 10 weeks reduced insomnia, adjusted difference=4.78 (95% C.I. 4.29;5.26), p<.0001, d=1.11, paranoia, adjusted difference=-2.22 (95% C.I. -2.98;-1.45), p<.0001, d=0.19, and hallucinations, adjusted difference=-1.58 (95% C.I. -1.98;-1.18), p<.0001, d=0.24. Insomnia was a mediator of change in paranoia and hallucinations. There were improvements in other mental health outcomes. No adverse events were reported. Interpretation: This is the largest randomised controlled trial of psychological intervention for a mental health problem. It provides strong evidence that insomnia is a causal factor in the occurrence of psychotic experiences and other mental health problems. Whether the results generalise beyond a student population requires testing. The treatment of disrupted sleep may require a higher priority in mental health provision.

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Uncontrolled Keywords: sleep, mental health, randomised controlled trial, mediation analysis
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Divisions: Academic Departments > Institute of Health and Society
Depositing User: Elaine Walklet
Date Deposited: 07 Aug 2017 11:14
Last Modified: 13 Sep 2017 13:15
URI: https://eprints.worc.ac.uk/id/eprint/5581

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