University of Worcester Worcester Research and Publications

Time to ‘Couple’ Redox Biology with Exercise Immunology

Wadley, A. J. and Coles, Steven ORCID: (2022) Time to ‘Couple’ Redox Biology with Exercise Immunology. In: Oxidative Eustress in Exercise Physiology. Oxidative Stress and Disease . CRC Press, Abingdon, pp. 85-94. ISBN 9780367508760; eBook: 9781003051619

Book Chapter_Wadley and Coles (2021) FINAL.pdf - Accepted Version

Download (526kB) | Preview


Regular moderate-intensity exercise is known to have both anti-inflammatory and antioxidant roles in humans, whereas intense exercise is commonly associated with both impaired immune function and heightened oxidative stress. The disciplines of immunology and redox biology are therefore regularly coinvestigated in the context of exercise; however, this has primarily been limited to monitoring changes in extracellular biomarkers (i.e., plasma, serum and saliva). Redox reactions mediate multiple aspects of innate and adaptive immunity. Exercise modulates innate (e.g., wound healing) and adaptive (e.g., vaccination response) immunity; however, only recently has the link between altered immune cell redox state, immune cell function and exercise been established. Accumulating evidence over the last 15 years indicates that redox reactions regulate skeletal muscle physiology. A role for redox reactions (i.e., reversible cysteine thiol oxidation) in modulating the benefits of exercise on immunity, therefore, seems highly intuitive. In this chapter, we review the current literature on redox exercise immunology and discuss how methodological issues largely explain the gaps in our knowledge. We close by suggesting how modern advances in biomedical sciences could benefit the field of redox exercise immunology and propose future areas of investigation, including immunometabolism and extracellular vesicle tissue crosstalk.

Item Type: Book Section
Additional Information:

This is an Accepted Manuscript of a book chapter published by CRC Press in 'Oxidative Eustress in Exercise Physiology' on June 10, 2022, available online:

Uncontrolled Discrete Keywords: leukocyte, physical activity, immunity, thiols, reductive stress
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: College of Health, Life and Environmental Sciences > School of Science and the Environment
Related URLs:
Copyright Info: 2022 Taylor & Francis Group, LLC
Depositing User: Steven Coles
Date Deposited: 13 Sep 2021 09:03
Last Modified: 10 Jun 2023 01:00

Actions (login required)

View Item View Item
Worcester Research and Publications is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.