University of Worcester Worcester Research and Publications

Genome-wide association study of suicidal behaviour severity in mood disorders

Zai, C.C., Fabbri, C., Hosang, G.M., Zhang, R.S., Koyama, E., de Luca, V., Tiwari, A.K., King, N., Strauss, J., Jones, I., Jones, Lisa ORCID:, Breen, G., Farmer, A.E., McGuffin, P., Vincent, J.B., Kennedy, J.L. and Lewis, C.M. (2021) Genome-wide association study of suicidal behaviour severity in mood disorders. The World Journal of Biological Psychiatry,. ISSN Print ISSN: 1562-2975 Online ISSN: 1814-1412

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Suicide is a major public health problem and it has a prominent genetic component. We performed a genome-wide association study (GWAS) of suicidal behaviour severity.

Suicide behaviour severity was assessed within the Schedules for Clinical Assessment in Neuropsychiatry in our mood disorder sample (n = 3506) for the GWAS. We also performed polygenic risk score analyses to explore genetic sharing between suicidal behaviour severity and a number of phenotypes, including bipolar disorder, major depressive disorder, alcoholism, post-traumatic stress disorder, impulsivity, insomnia, educational attainment, loneliness, maltreatment, and amygdala volume.

We did not detect genome-wide significant findings at the single-marker or gene level. We report a number of suggestive single-marker and gene-based findings. Our polygenic risk score analyses did not yield significant findings with these phenotypes.

Larger sample sizes are required to detect moderate effects.

Item Type: Article
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Uncontrolled Discrete Keywords: suicidality, Genome-Wide Association Study, bipolar disorder, major depressive disorder, suicidal behaviour severity
Divisions: College of Health, Life and Environmental Sciences > School of Allied Health and Community
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Depositing User: Lisa Jones
Date Deposited: 23 Jun 2021 10:07
Last Modified: 23 Jun 2021 10:07

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