Genome-wide association study of suicidal behaviour severity in mood disorders

Zai, C.C., Fabbri, C., Hosang, G.M., Zhang, R.S., Koyama, E., de Luca, V., Tiwari, A.K., King, N., Strauss, J., Jones, I., Jones, Lisa ORCID: https://orcid.org/0000-0002-5122-8334, Breen, G., Farmer, A.E., McGuffin, P., Vincent, J.B., Kennedy, J.L. and Lewis, C.M. (2021) Genome-wide association study of suicidal behaviour severity in mood disorders. The World Journal of Biological Psychiatry,. ISSN Print ISSN: 1562-2975 Online ISSN: 1814-1412

Abstract

Objective
Suicide is a major public health problem and it has a prominent genetic component. We performed a genome-wide association study (GWAS) of suicidal behaviour severity.

Methods
Suicide behaviour severity was assessed within the Schedules for Clinical Assessment in Neuropsychiatry in our mood disorder sample (n = 3506) for the GWAS. We also performed polygenic risk score analyses to explore genetic sharing between suicidal behaviour severity and a number of phenotypes, including bipolar disorder, major depressive disorder, alcoholism, post-traumatic stress disorder, impulsivity, insomnia, educational attainment, loneliness, maltreatment, and amygdala volume.

Results
We did not detect genome-wide significant findings at the single-marker or gene level. We report a number of suggestive single-marker and gene-based findings. Our polygenic risk score analyses did not yield significant findings with these phenotypes.

Conclusions
Larger sample sizes are required to detect moderate effects.

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