University of Worcester Worcester Research and Publications

Adverse childhood experiences and postpartum depression in bipolar disorder

Perry, Amy ORCID:, Gordon-Smith, Katherine ORCID:, Di Florio, A., Fraser, C., Craddock, N., Jones, Lisa ORCID: and Jones, I. (2020) Adverse childhood experiences and postpartum depression in bipolar disorder. Journal of Affective Disorders, 263. pp. 661-666. ISSN Online: 0165-0327

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Background Women are particularly vulnerable to recurrence of bipolar disorder (BD) following childbirth. Risk of postpartum psychosis (PP) is especially high, but postpartum depression (PPD) is also common. Adverse childhood experiences (ACEs) have not been associated with PP, but have been associated with PPD in non-bipolar samples. The relationship between ACEs and PPD within BD remains to be investigated. Here, we examined this association in a large, well-defined sample of women with BD. Methods Participants were 575 parous women with DSM-IV BD. Lifetime psychopathology, including perinatal, was assessed via semi-structured interview and case-notes. ACEs, assessed via self-report and case-notes, were compared between women with lifetime PPD (n=368) and those without a lifetime history of perinatal mood episodes (n=207). Results In univariate analysis exposure to 3 or more ACEs, and to childhood abuse specifically, was significantly associated with PPD (p=0.026 and 0.041 respectively), but this did not remain significant after adjusting for lifetime number of episodes of depression and parity. Post-hoc analysis revealed more frequent episodes of depression to be associated with both a history of 3 or more ACEs and of childhood abuse. Limitations Limited range of ACEs assessed and potential recall bias. Conclusions Increased frequency of ACEs and particularly childhood abuse was associated with more frequent lifetime episodes of depression, but not specifically episodes with postpartum onset. Understanding factors that media.

Item Type: Article
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Uncontrolled Discrete Keywords: bipolar disorder, postpartum depression, postnatal depression, adverse childhood experiences, childhood abuse, childhood trauma
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: College of Health, Life and Environmental Sciences > School of Allied Health and Community
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Depositing User: Katherine Gordon-Smith
Date Deposited: 29 Nov 2019 16:53
Last Modified: 11 Nov 2020 01:00

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