University of Worcester Worcester Research and Publications

Modified Release of Beclometasone Dipropionate from Chitosan-based Spray-dried Respirable Powders

Learoyd, T.P., Burrows, J.L., French, E. and Seville, Peter C. ORCID: (2008) Modified Release of Beclometasone Dipropionate from Chitosan-based Spray-dried Respirable Powders. Powder Technology, 187 (3). pp. 231-238. ISSN Print : 0032-5910 Online: 1873-328X

Full text not available from this repository. (Request a copy)


Dry powders for inhalation were prepared by spray drying a 30% v/v aqueous ethanol formulation containing beclometasone dipropionate (BDP), lactose, leucine and chitosan (low, medium or high molecular weight (MW), or combinations thereof). Following physical characterisation of the powders, the aerosolisation and dissolution properties of the powders were investigated using Multi-Stage Liquid Impinger and USP II dissolution apparatus, respectively. The powders were highly dispersible, with emitted doses in excess of 90% of loaded powder aerosolised from a Spinhaler dry powder inhaler. The fine particle fraction (FPF) was observed to decrease, whereas the time for 100% drug release increased, with increasing chitosan MW. For example, the low MW formulation exhibited an FPF of 64% and a 100% dissolution time of 2 h, whereas the high MW formulation demonstrated an FPF of 54% and a dissolution time of 12 h. These powders would be anticipated to deposit predominately in the lower regions of the lung following inhalation, and then undergo delayed rather than instantaneous drug release, offering the potential to reduce dosing frequency and improve patient compliance.

Item Type: Article
Additional Information:

The full-text cannot be supplied for this item. Please check availability with your local library or Interlibrary Requests Service.

Uncontrolled Discrete Keywords: spray-drying, leucine, modified release, inhalation, aerosolisation, chitosan
Divisions: College of Health, Life and Environmental Sciences > School of Science and the Environment
Related URLs:
Depositing User: Peter Seville
Date Deposited: 17 Jun 2019 10:47
Last Modified: 17 Jun 2020 17:30

Actions (login required)

View Item View Item
Worcester Research and Publications is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.