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Sleep Loss as a Trigger of Mood Episodes in Bipolar Disorder: Individual Differences Based on Diagnostic Subtype and Gender

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Swaden Lewis, K., Gordon-Smith, Katherine ORCID: https://orcid.org/0000-0003-4083-1143, Forty, L., Di Florio, A., Craddock, N., Jones, Lisa ORCID: https://orcid.org/0000-0002-5122-8334 and Jones, I. (2017) Sleep Loss as a Trigger of Mood Episodes in Bipolar Disorder: Individual Differences Based on Diagnostic Subtype and Gender. British Journal of Psychiatry, 211 (3). pp. 169-174. ISSN 0007-1250 Online:1472-1465

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Official URL: http://bjp.rcpsych.org/content/211/3/169

Abstract

Background: Sleep loss may trigger mood episodes in people with bipolar disorder (BD) but individual differences could influence vulnerability to this trigger.

Aims: To determine whether bipolar subtype (BD-I or BD-II) and gender were associated with vulnerability to the sleep loss trigger.

Method: During a semi-structured interview, 3140 individuals (68% female) with BD (66% BD-I) reported whether sleep loss had triggered episodes of high or low mood. DSM-IV diagnosis of bipolar subtype was derived from case note and interview data.

Results: Sleep loss triggering episodes of high mood was associated with female gender (OR = 1.43, 95% CI 1.17-1.75, P <.001) and BD-I subtype (OR = 2.81, 95% CI 2.26-3.50, P <.001). Analyses on sleep loss triggering low mood were not significant following adjustment for confounders.

Conclusions: Gender and bipolar subtype may increase vulnerability to high mood following sleep deprivation. This should be considered in situations where patients encounter sleep disruption, such as shift-work and international travel.

Item Type:	Article
Additional Information:	The full-text can be accessed via the Official URL.
Uncontrolled Discrete Keywords:	sleep loss, bipolar disorder, diagnostic subtype, gender
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions:	College of Health, Life and Environmental Sciences > School of Allied Health and Community
Related URLs:	http://bjp.rcpsych.org/
Depositing User:	Katherine Gordon-Smith
Date Deposited:	19 May 2017 07:23
Last Modified:	09 Jul 2020 11:06
URI:	https://eprints.worc.ac.uk/id/eprint/5515

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