University of Worcester Worcester Research and Publications

Identifying Risk Factors for Postpartum Mood Episodes in Bipolar Disorder – A UK Prospective Study

Perry, Amy ORCID:, Gordon-Smith, Katherine ORCID:, Di Florio, A., Forty, L., Craddock, N., Jones, Lisa ORCID: and Jones, I. (2016) Identifying Risk Factors for Postpartum Mood Episodes in Bipolar Disorder – A UK Prospective Study. In: 18th Annual Conference of the International Society for Bipolar Disorders & 8th Biennial Conference of the International Society for Affective Disorders, 13th - 16th July 2016, Amsterdam, The Netherlands. (Unpublished)

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Background and Aims: Women with bipolar disorder are vulnerable to episodes postpartum, but risk factors are poorly understood. We are exploring risk factors for postpartum mood episodes in women with bipolar disorder using a prospective longitudinal design.

Methods: Pregnant women with lifetime DSM-IV bipolar disorder are being recruited into the Bipolar Disorder Research Network ( Baseline assessments during late pregnancy include lifetime psychopathology and potential risk factors for perinatal episodes such as medication use, sleep, obstetric factors, and psychosocial factors. Blood samples are taken for genetic analysis. Perinatal psychopathology is assessed via follow-up interview at 12-weeks postpartum. Interview data are supplemented by clinician questionnaires and case-note review. Potential risk factors will be compared between women who experience perinatal episodes and those who remain well.

Results: 80 participants have been recruited to date. 32/61 (52%) women had a perinatal recurrence by follow-up. 16 (26%) had onset in pregnancy. 21 (34%) had postpartum onset, 19 (90%) within 6-weeks of delivery: 11 (18%) postpartum psychosis, 5 (8%) postpartum hypomania, 5 (8%) postpartum depression. Postpartum relapse was more frequent in women with bipolar-I than bipolar-II disorder (45% vs 17%). 62% women with postpartum relapse took prophylactic medication peripartum and almost all received care from secondary psychiatric services (95%).

Conclusions: Rate of postpartum relapse is high, despite most women receiving specialist care and medication perinatally. A larger sample size will allow us to examine potential risk factors for postpartum episodes, which will assist in providing accurate and personalised advice to women with bipolar disorder who are considering pregnancy.

Item Type: Conference or Workshop Item (Poster)
Additional Information:

The published abstract for the poster is available in the journal 'Bipolar Disorder', Volume 18, Issue SI, P-363 on p. 183.

Uncontrolled Discrete Keywords: risk, postpartum mood episodes, bipolar disorder
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: College of Health, Life and Environmental Sciences > School of Allied Health and Community
Related URLs:
Depositing User: Katherine Gordon-Smith
Date Deposited: 22 Sep 2016 14:25
Last Modified: 17 Jun 2020 17:13

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