Abu-Akel, A., Clark, J., Perry, Amy ORCID: https://orcid.org/0000-0002-9381-6636, Wood, S.J., Forty, L., Craddock, N., Jones, I., Gordon-Smith, Katherine ORCID: https://orcid.org/0000-0003-4083-1143 and Jones, Lisa ORCID: https://orcid.org/0000-0002-5122-8334 (2017) Autistic and Schizotypal Traits and Global Functioning in Bipolar I Disorder. Journal of Affective Disorders, 207. pp. 268-275. ISSN 0165-0327
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Abstract
Objective: To determine the expression of autistic and positive schizotypal traits in a large sample of adults with bipolar I disorder (BD-I), and the effect of co-occurring autistic and positive schizotypal traits on global functioning in BD-I.
Method: Autistic and positive schizotypal traits were self-assessed in 797 individuals with BD-I recruited by the Bipolar Disorder Research Network. Differences in global functioning (rated using the Global Assessment Scale) during lifetime worst depressive and manic episodes (GASD and GASM respectively) were calculated in groups with high/low autistic and positive schizotypal traits. Regression analyses assessed the interactive effect of autistic and positive schizotypal traits on global functioning.
Results: 47.2% (CI=43.7-50.7%) showed clinically significant levels of autistic traits, and 23.22% (95% CI=20.29-26.14) showed clinically significant levels of positive schizotypal traits. In the worst episode of mania, the high autistic, high positive schizotypal group had better global functioning compared to the other groups. Individual differences analyses showed that high levels of co-occurring traits were associated with better global functioning in both mood states.
Limitations: Autistic and schizotypal traits were assessed using self-rated questionnaires.
Conclusions: Expression of autistic and schizotypal traits in adults with BD-I is prevalent, and may be important to predict illness aetiology, prognosis, and diagnostic practices in this population. Future work should focus on replicating these findings in independent samples, and on the biological and/or psychosocial mechanisms underlying better global functioning in those who have high levels of both autistic and positive schizotypal traits.
Item Type: | Article |
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Additional Information: | Staff and students at the University of Worcester can access the full-text of the online published article via the online Library Search. External users should check availability with their local library or Interlibrary Requests Service. |
Uncontrolled Discrete Keywords: | autism, global functioning, psychosis, schizophrenia, schizotypy |
Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
Divisions: | College of Health, Life and Environmental Sciences > School of Allied Health and Community |
Related URLs: | |
Depositing User: | Lisa Jones |
Date Deposited: | 22 Sep 2016 12:22 |
Last Modified: | 09 Jul 2020 11:37 |
URI: | https://eprints.worc.ac.uk/id/eprint/4912 |
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