Naghettini, A.V., Nogueira, P.C.K., Juliano, M., Bueno, Allain ORCID: https://orcid.org/0000-0002-9456-8558, Casarini, D.E. and Carvalhaes, J.T. (2001) Tubular Urinary Enzymes in Acute Post-infectious Glomerulonephritis. Pediatric Nephrology, 16 (9). pp. 719-722. ISSN Print 0931-041X Online 1432-198X
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Abstract
Tubular function of 17 pediatric patients with a mild form of acute post-infectious glomerulonephritis was prospectively evaluated by assessment of the urinary activity of proximal and distal tubule enzymes. Neutral-like endopeptidase (NEP-like) and angiotensin-converting enzyme (ACE) were the proximal tubule enzymes assessed, while prolyl-endopeptidase (PE) and serine-endopeptidase H1 and H2 were the distal tubule enzymes analyzed. Urine was collected at diagnosis (T0) and after 2 (T2) and 6 (T6) months of follow-up. NEP-like enzyme activity (nmol/mg creatinine; median±quartile range) was increased at diagnosis, and this remained stable during the first 6 months (T0 18.30±83.26, T2 17.32±49.56, T6 23.38±107.18). Urinary activity of the other enzymes was as follows: ACE (mU/ml per mg creatinine) T0 0.08±0.16, T2 0.06±0.10, T6 0.18±0.29; PE (nmol/mg creatinine) T0 6.70±84.87, T2 9.55±69.00, T6 13.67±28.70; serine-endopeptidase H1 (nmol/mg creatinine) T0 7.86±26.95, T2 17.17±59.37, T6 18.19± 79.14; and serine-thiol-endopeptidase H2 (nmol/mg creatinine) T0 3.06±21.97, T2 12.06±32.42, T6 16.22± 44.06. Thirty other healthy children matched for age and gender were considered as a control group. This group was assessed once and the results were: NEP-like activity 6.05±10.54, ACE 0.11±0.22, PE 7.10±13.36, H1 5.00±17.30, and H2 6.00±20.16. In conclusion, we observed that NEP-like and H1 enzymes exhibited significant increased urinary activity 6 months after the diagnosis. This increase occurred in spite of the disappearance of clinical symptoms, which occurred 2 months after the diagnosis. We believe that the increase in urinary enzymatic activity could be a manifestation of a silent tubular dysfunction following an episode of acute post-infectious glomerulonephritis.
Item Type: | Article |
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Additional Information: | Staff and students at the University of Worcester can access the full-text via the UW online library search. External users should check availability with their local library or Interlibrary Requests Service. |
Uncontrolled Discrete Keywords: | Glomerulonephritis, acute disease, Endopeptidases, Peptide hydrolases, renal tubular function |
Subjects: | Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology |
Divisions: | College of Health, Life and Environmental Sciences > School of Science and the Environment |
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Depositing User: | Tanya Buchanan |
Date Deposited: | 12 Aug 2016 13:31 |
Last Modified: | 17 Jun 2020 17:13 |
URI: | https://eprints.worc.ac.uk/id/eprint/4809 |
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