University of Worcester Worcester Research and Publications

Lipid Metabolism of Monosodium Glutamate Obese Rats after Partial Removal of Adipose Tissue

Bueno, Allain ORCID:, Oyama, L.M., Estadella, D., Habitante, C.A., Bernardes, B.S.S., Ribeiro, E.B. and Oller do Nascimento, C.M. (2005) Lipid Metabolism of Monosodium Glutamate Obese Rats after Partial Removal of Adipose Tissue. Physiological Research, 54 (1). pp. 57-65. ISSN Print 0862-8408 Online 1802-9973

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We analyzed the effects of partial fat pad removal on retroperitoneal and epididymal fat depots and carcass metabolism of control (C) and MSG-obese (M) rats. Three-month-old C and M male Wistar rats were submitted to either partial surgical excision of epididymal and retroperitoneal fat tissue (lipectomy, L) or sham surgery (S) and studied after 7 or 30 days. Retroperitoneal and epididymal tissue re-growth after lipectomy was not observed, as indicated by the low pads weight of the L groups. The lipolysis rate was stimulated in LC7 and LM7, probably due to surgical stress and low insulin levels. In LM7, but not in LC7, in vivo lipogenesis rate increased in retroperitoneal and epididymal fat tissue, as did the diet-derived lipid accumulation in epididymal fat tissue. Although these local increases were no longer present in LM30, this group showed a large increase in the percentage of small area adipocytes in both pads as well as increased carcass lipogenesis rate. The present data showed that the partial removal of fat depots affected the metabolism of control and MSG-obese rats differently. In the obese animals only, it stimulated both local and carcass lipogenesis rate as well as adipocyte differentiation, i.e. responses likely to favor excised tissue re-growth and/or compensatory growth of non-excised depots.

Item Type: Article
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Uncontrolled Discrete Keywords: lipectomy, MSG rats, adipocyte area, lipogenesis rate, lipolysis rate
Subjects: Q Science > Q Science (General)
Q Science > QH Natural history > QH301 Biology
Q Science > QP Physiology
Divisions: College of Health, Life and Environmental Sciences > School of Science and the Environment
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Depositing User: Tanya Buchanan
Date Deposited: 12 Aug 2016 13:13
Last Modified: 17 Jun 2020 17:13

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