University of Worcester Worcester Research and Publications

Rapid Cycling as a Feature of Bipolar Disorder and Comorbid Migraine

Gordon-Smith, Katherine ORCID:, Forty, L., Chan, C., Knott, Sarah, Jones, I., Craddock, N. and Jones, Lisa ORCID: (2015) Rapid Cycling as a Feature of Bipolar Disorder and Comorbid Migraine. Journal of Affective Disorders, 175. pp. 320-324. ISSN Online: 0165-0327

This is the latest version of this item.

1-s2.0-S0165032715000282-main.pdf - Published Version
Available under License Creative Commons Attribution.

Download (186kB) | Preview


Previous research has suggested the clinical profile of individuals with bipolar disorder (BD) differs according to the presence or absence of comorbid migraine. We aimed to determine the clinical characteristics that differentiate individuals with BD with and without comorbid migraine in a large, representative, clinically well-characterised UK sample.
The lifetime clinical characteristics of 1488 individuals with BD (BPI n=1120, BPII n=368) with and without comorbid migraine were compared (n=375 vs. n=1113 respectively).
Individuals with BD and comorbid migraine had a distinctive set of lifetime clinical characteristics. A multivariate model showed that consistent with previous studies those with comorbid migraine were significantly more likely to be female (OR=2.099, p=0.005) and have comorbid panic attacks (OR=1.842, p=0.004). A novel finding was that even after controlling for other differences, the individuals with BD and comorbid migraine were more likely to have a rapid cycling illness course (OR=1.888, p=0.002).
Presence of migraine was assessed using self report measures. Cross-sectional study design limits investigations of bidirectional associations between migraine and bipolar disorder.
Comorbid migraine in BD may represent a more homogenous subtype of BD with an unstable rapid cycling course. Identifying individuals with BD and comorbid migraine may be of use in a clinical setting and this subgroup could be the focus of future aetiological studies.

Item Type: Article
Additional Information:

The full-text can be accessed via the official URL.

Uncontrolled Discrete Keywords: bipolar disorder, comorbidity, migraine, rapid cycling
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: College of Health, Life and Environmental Sciences > School of Allied Health and Community
Related URLs:
Copyright Info: Open Access article
Depositing User: Lisa Jones
Date Deposited: 18 Dec 2015 08:36
Last Modified: 09 Jul 2020 10:59

Available Versions of this Item

Actions (login required)

View Item View Item
Worcester Research and Publications is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.