Shahraki, T., Rostami, K., Shahraki, M., Bold, Justine, Danciu, M., Al Dulaimi, D., Villanacci, V. and Bassotti, G. (2012) Microscopic Enteritis; Clinical Features and Correlations with Symptoms. Gastroenterol Hepatol Bed Bench., 5 (3). pp. 146-54. ISSN 2008-2258 Online: 2008-4234
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Abstract
Aim: To assess the clinical characteristic of CD as well as correlation of symptoms and the degrees of intestinal mucosal lesions in Iranian children.
Background: Microscopic Enteritis (Marsh 0-II) is associated with malabsorption.
Patients and methods: From August 2005 to September 2009, 111 cases with malabsorption and classical gastrointestinal symptoms were evaluated.
Results: The mean (±SD) age of children with CD was 4.9±3.5 years (range, 6 month - 16 years) and the mean duration of symptoms was 8 ± 20.5 months. 50 cases (45%) were female and 61 cases (55%) were male. The most common clinical presentation was failure to thrive in 72%, chronic diarrhea in 65.8% and Iron deficiency anemia in 59.5%. Sensitivity of EMA was 100% in patients with Marsh IIIb and Marsh IIIc. EMA was also positive in 77% of cases with Marsh 0, 18% in Marsh I, 44% in Marsh II and 81.8% in patients with Marsh IIIa.
Conclusion: Histopathology did not reflect the severity of gluten sensitivity. This would suggest that the degree of intestinal mucosal damage might not be a reliable prognostic factor. Significant symptoms can be present with minor histological change on biopsy.
Item Type: | Article |
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Additional Information: | The full-text can be accessed via the Official URL. |
Uncontrolled Discrete Keywords: | coeliac disease, serology, histology, macroscopic enteritis |
Divisions: | College of Health, Life and Environmental Sciences > School of Allied Health and Community |
Related URLs: | |
Copyright Info: | Open Access |
Depositing User: | Justine Bold |
Date Deposited: | 07 Sep 2018 08:55 |
Last Modified: | 17 Jun 2020 17:04 |
URI: | https://eprints.worc.ac.uk/id/eprint/3301 |
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