The Role of Hormone Replacement Therapy (HRT) for the Prevention of Alzheimer's Disease in Postmenopausal Women

Alzheimer's disease (AD) disproportionately affects women and, in 2022, was the leading cause of female deaths. It has major psychosocial, physical and economic impacts which will become more pronounced with an ageing population. Current treatments focus on symptom control and do not affect disease course. Emerging evidence suggests that the prescription of perimenopausal hormone replacement therapy (HRT) may prevent the development of AD. The objective of this narrative review is to synthesise and analyse relevant literature regarding HRT and AD prognosis in pre‐ and postmenopausal women to establish the current knowledge and provide a foundation for future research.