University of Worcester Worcester Research and Publications

Mobile Flowering Locus T RNA – Biological Relevance and Biotechnological Potential

Yu, Z., Chen, W., Wang, Y., Zhang, P., Shi, N. and Hong, Yiguo (2022) Mobile Flowering Locus T RNA – Biological Relevance and Biotechnological Potential. Frontiers in Plant Science, 12 (792192). ISSN 1664-462X

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Many systemically mobile mRNAs have been revealed in phloem. However, very few of them have been found to be of clear signaling functions. One of such rare examples is the mobile Flowering locus T (FT) mRNA despite the continuous debate about its mobility and biological relevance to the control of flowering time in plants. Nevertheless, accumulating evidence supports the notion of the long-distance movement of FT mRNA from leaf to shoot apex meristem and its role in flowering. In this review, we discuss the discovery of florigenic FT, the initial debate on long-distance movement of FT mRNA, emerging evidence to prove its mobility, and the use of mobile FT mRNA to generate heritable transgenerational gene editing in plants. We elaborate on evidence from virus-based RNA mobility assay, plant grafting, RNA with fluorescent protein labeling, and CRISPR/Cas9 gene-editing technology, to demonstrate that the FT mRNA besides the FT protein can move systemically and function as an integral component of the florigenic signal in flowering. We also propose a model to prompt further research on the molecular mechanism underlying the long-distance movement of this important mobile signaling RNA in plants.

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Copyright © 2022 Yu, Chen, Wang, Zhang, Shi and Hong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

This work was in part supported by grants from Ministry of Science and Technology of China (National Key R&D Program 2017YFE0110900), Ministry of Agriculture of the People’s Republic of China (National Transgenic Program of China 2016ZX08009001-004); National Natural Science Foundation of China (31200913 and 31872636); Zhejiang Provincial Natural Science Foundation (LY19C020002), China Scholarship Council (201709645003), the Entrepreneurship and Innovation Project for the Overseas Returnees (or Teams) in Hangzhou (4105C5062000611), and Hangzhou Normal University (Sino-EU Plant RNA Signaling S&T Platform Initiative 9995C5021841101).

Uncontrolled Discrete Keywords: florigen, Flowering Locus T, mRNA, long-distancing movement, mobile RNA-based genome editing
Divisions: College of Health, Life and Environmental Sciences > School of Science and the Environment
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Depositing User: Yiguo Hong
Date Deposited: 14 Feb 2022 15:59
Last Modified: 10 Mar 2022 12:29

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