University of Worcester Worcester Research and Publications

Dietary Fish Hydrolysate Improves Memory Performance Through Microglial Signature Remodeling During Aging

Chataigner, M., Lucas, C., Di Miceli, Mathieu ORCID:, Pallet, V., Laye, S., Mahaignerie, A., Bouvret, E., Dinnel, A.L. and Joffre, C. (2021) Dietary Fish Hydrolysate Improves Memory Performance Through Microglial Signature Remodeling During Aging. Frontiers in Nutrition, 8 (75029). ISSN 2296-861X

Chataigner Joffre Dinel et al 2021 Front Nutr.pdf - Published Version
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Brain aging is characterized by a chronic low-grade inflammation, which significantly impairs cognitive function. Microglial cells, the immunocompetent cells of the brain, present a different phenotype, switching from a homeostatic signature (M0) to a more reactive phenotype called “MGnD” (microglial neurodegenerative phenotype), leading to a high production of pro-inflammatory cytokines. Furthermore, microglial cells can be activated by age-induced gut dysbiosis through the vagus nerve or the modulation of the peripheral immune system. Nutrients, in particular n-3 long chain polyunsaturated fatty acids (LC-PUFAs) and low molecular weight peptides, display powerful immunomodulatory properties, and can thus prevent age-related cognitive decline. The objective of this study was to investigate the effects of n-3 LC-PUFAs and low molecular weight peptides contained in a marine by-product-derived hydrolysate on microglial phenotypes and intestinal permeability and their consequences on cognition in mice. We demonstrated that the hydrolysate supplementation for 8 weeks prevented short- and long-term memory decline during aging. These observations were linked to the modulation of microglial signature. Indeed, the hydrolysate supplementation promoted homeostatic microglial phenotype by increasing TGF-β1 expression and stimulated phagocytosis by increasing Clec7a expression. Moreover, the hydrolysate supplementation promoted anti-inflammatory intestinal pathway and tended to prevent intestinal permeability alteration occurring during aging. Therefore, the fish hydrolysate appears as an interesting candidate to prevent cognitive decline during aging.

Item Type: Article
Uncontrolled Discrete Keywords: n-3 long chain PUFA, low molecular weight peptides, microglia, memory, hydrolysate, cognitive decline, aging
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: College of Health, Life and Environmental Sciences > School of Science and the Environment
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Copyright Info: Open Access, © 2021 Chataigner, Lucas, Di Miceli, Pallet, Laye, Mehaignerie, Bouvret, Dinel and Joffre. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forum
Depositing User: Dr Mathieu Di Miceli
Date Deposited: 26 Nov 2021 18:31
Last Modified: 26 Nov 2021 18:31

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