University of Worcester Worcester Research and Publications

PUFA and their derivatives in neurotransmission and synapses: a new hallmark of synaptopathies

Di Miceli, Mathieu ORCID:, Bosch-Bouju, C. and Layé, S. (2020) PUFA and their derivatives in neurotransmission and synapses: a new hallmark of synaptopathies. The Proceedings of the Nutrition Society, 79 (4). pp. 388-403. ISSN 1475-2719

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PUFA of the n-3 and n-6 families are present in high concentration in the brain where they are major components of cell membranes. The main forms found in the brain are DHA (22 :6, n-3) and arachidonic acid (20:4, n-6). In the past century, several studies pinpointed that modifications of n-3 and n-6 PUFA levels in the brain through dietary supply or genetic means are linked to the alterations of synaptic function. Yet, synaptopathies emerge as a common characteristic of neurodevelopmental disorders, neuropsychiatric diseases and some neurodegenerative diseases. Understanding the mechanisms of action underlying the activity of PUFA at the level of synapses is thus of high interest. In this frame, dietary supplementation in PUFA aiming at restoring or promoting the optimal function of synapses appears as a promising strategy to treat synaptopathies. This paper reviews the link between dietary PUFA, synapse formation and the role of PUFA and their metabolites in synaptic functions.

Item Type: Article
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Conference on ‘Malnutrition in an Obese World: European Perspectives’.

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Uncontrolled Discrete Keywords: synaptic plasticity, DHA, EPA, endocannabinoids, oxylipins
Divisions: College of Health, Life and Environmental Sciences > School of Science and the Environment
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Depositing User: Mathieu Di Miceli
Date Deposited: 06 Oct 2021 11:18
Last Modified: 07 Dec 2021 16:51

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