University of Worcester Worcester Research and Publications

Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons.

Berland, C., Montalban, E., Perrin, E., Di Miceli, Mathieu ORCID:, Nakamura, Y., Martinat, M., Sullivan, M., Davis, X.S., Shenasa, M.A., Martin, C., Tolu, S., Marti, F., Caille, S., Castel, J., Perez, S., Salinas, C.G., Morel, C., Hecksher-Sørensen, J., Cador, M., Fioramonti, X., Tschöp, M.H., Layé, S., Venance, L., Faure, P., Hnasko, T.S., Small, D.M., Gangarossa, G. and Luquet, S.H. (2020) Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons. Cell metabolism, 31 (4). 773-790.e11. ISSN Print: 1550-4131 Online: 1932-7420

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Energy-dense food alters dopaminergic (DA) transmission in the mesocorticolimbic (MCL) system and can promote reward dysfunctions, compulsive feeding, and weight gain. Yet the mechanisms by which nutrients influence the MCL circuitry remain elusive. Here, we show that nutritional triglycerides (TGs), a conserved post-prandial metabolic signature among mammals, can be metabolized within the MCL system and modulate DA-associated behaviors by gating the activity of dopamine receptor subtype 2 (DRD2)-expressing neurons through a mechanism that involves the action of the lipoprotein lipase (LPL). Further, we show that in humans, post-prandial TG excursions modulate brain responses to food cues in individuals carrying a genetic risk for reduced DRD2 signaling. Collectively, these findings unveil a novel mechanism by which dietary TGs directly alter signaling in the reward circuit to regulate behavior, thereby providing a new mechanistic basis by which energy-rich diets may lead to (mal)adaptations in DA signaling that underlie reward deficit and compulsive behavior.

Item Type: Article
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Uncontrolled Discrete Keywords: high-fat diet, lipoprotein-lipase, nucleus-accumbens, receptor gene, D2 receptors, energy balance, weight-gain, food-intake, long-term, brain
Divisions: College of Health, Life and Environmental Sciences > School of Science and the Environment
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Depositing User: Mathieu Di Miceli
Date Deposited: 06 Oct 2021 11:17
Last Modified: 07 Dec 2021 16:52

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