Psychological intervention, antipsychotic medication or a combined treatment for adolescents with a first episode of psychosis: the MAPS feasibility three-arm RCT

Morrison, A.P., Pyle, M., Byrne, R., Broome, M., Freeman, D., Johns, L., James, A., Husrat, H., Whale, R., MacLennon, G., Norrie, J., Hudson, J., Peters, S., Davies, L., Bowe, S., Smith, Jo, Shiers, D., Joyce, E., Jones, W., Hollis, C. and Maughan, D. (2021) Psychological intervention, antipsychotic medication or a combined treatment for adolescents with a first episode of psychosis: the MAPS feasibility three-arm RCT. Project Report. National Institute for Health Research (NIHR).

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Abstract

Background: When psychosis emerges in young people there is a risk of poorer outcomes, and
access to evidence-based treatments is paramount. The current evidence base is limited. Antipsychotic
medications show only a small benefit over placebo, but young people experience more side effects
than adults. There is sparse evidence for psychological intervention. Research is needed to determine
the clinical effectiveness and cost-effectiveness of psychological intervention versus antipsychotic
medication versus a combined treatment for adolescents with psychosis.
Objectives: The objective of Managing Adolescent first-episode Psychosis: a feasibility Study (MAPS)
was to determine the feasibility of conducting a definitive trial to answer the question of clinical
effectiveness and cost-effectiveness of these three treatment options.
Design: This was a prospective, randomised, open-blinded, evaluation feasibility trial with a single blind.
Participants were allocated 1 : 1 : 1 to receive antipsychotic medication, psychological intervention or a
combination of both. A thematic qualitative study explored the acceptability and feasibility of the trial.
Setting: Early intervention in psychosis services and child and adolescent mental health services in
Manchester, Oxford, Lancashire, Sussex, Birmingham, Norfolk and Suffolk, and Northumberland,
Tyne and Wear.
Participants: People aged 14–18 years experiencing a first episode of psychosis either with an
International Classification of Diseases, Tenth Revision, schizophrenia spectrum diagnosis or meeting the
entry criteria for early intervention in psychosis who had not received antipsychotic medication or
psychological intervention within the last 3 months.
Interventions: Psychological intervention involved up to 26 hours of cognitive–behavioural therapy
and six family intervention sessions over 6 months, with up to four booster sessions. Antipsychotic
medication was prescribed by the participant’s psychiatrist in line with usual practice. Combined
treatment was a combination of psychological intervention and antipsychotic medication.
Main outcome measures: The primary outcome was feasibility (recruitment, treatment adherence and
retention). We used a three-stage progression criterion to determine feasibility. Secondary outcomes
were psychosis symptoms, recovery, anxiety and depression, social and educational/occupational
functioning, drug and alcohol use, health economics, adverse/metabolic side effects and adverse/
serious adverse events.
Results: We recruited 61 out of 90 (67.8%; amber zone) potential participants (psychological
intervention, n = 18; antipsychotic medication, n = 22; combined treatment, n = 21). Retention to
follow-up was 51 out of 61 participants (83.6%; green zone). In the psychological intervention arm
and the combined treatment arm, 32 out of 39 (82.1%) participants received six or more sessions of
cognitive–behavioural therapy (green zone). In the combined treatment arm and the antipsychotic
medication arm, 28 out of 43 (65.1%) participants received antipsychotic medication for 6 consecutive
weeks (amber zone). There were no serious adverse events related to the trial and one related adverse
event. Overall, the number of completed secondary outcome measures, including health economics,
was small.
Limitations: Medication adherence was determined by clinician report, which can be biased. The
response to secondary outcomes was low, including health economics. The small sample size obtained
means that the study lacked statistical power and there will be considerable uncertainty regarding
estimates of treatment effects.
Conclusions: It is feasible to conduct a trial comparing psychological intervention with antipsychotic
medication and a combination treatment in young people with psychosis with some adaptations to the
design, including adaptations to collection of health economic data to determine cost-effectiveness.
Future work: An adequately powered definitive trial is required to provide robust evidence.
Trial registration: Current Controlled Trials ISRCTN80567433.
Funding: This project was funded by the National Institute for Health Research (NIHR) Health
Technology Assessment programme and will be published in full in Health Technology Assessment;
Vol. 25, No. 4. See the NIHR Journals Library website for further project information.

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