University of Worcester Worcester Research and Publications

Synthesis of Silver Nanoparticles Using Curcumin-Cyclodextrins Loaded into Bacterial Cellulose-Based Hydrogels for Wound Dressing Applications.

Gupta, A. ORCID:, Briffa, S.M., Swingler, S., Gibson, H., Kannappan, V., Adamus, G., Kowalczuk, M. ORCID:, Martin, Claire ORCID: and Radecka, I. ORCID: (2020) Synthesis of Silver Nanoparticles Using Curcumin-Cyclodextrins Loaded into Bacterial Cellulose-Based Hydrogels for Wound Dressing Applications. Biomacromolecules, 21 (5). pp. 1802-1811. ISSN 1526-4602

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Chronic wounds are often recalcitrant to treatment because of high microbial bioburden and the problem of microbial resistance. Silver is a broad-spectrum natural antimicrobial agent with wide applications extending to proprietary wound dressings. Recently, silver nanoparticles have attracted attention in wound management. In the current study, the green synthesis of nanoparticles was accomplished using a natural reducing agent, curcumin, which is a natural polyphenolic compound that is well-known as a wound-healing agent. The hydrophobicity of curcumin was overcome by its microencapsulation in cyclodextrins. This study demonstrates the production, characterization of silver nanoparticles using aqueous curcumin:hydroxypropyl-β-cyclodextrin complex and loading them into bacterial cellulose hydrogel with moist wound-healing properties. These silver nanoparticle-loaded bacterial cellulose hydrogels were characterized for wound-management applications. In addition to high cytocompatibility, these novel dressings exhibited antimicrobial activity against three common wound-infecting pathogenic microbes , , and .

Item Type: Article
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The full-text of the online final published version of article can be accessed via the official URL and is available to download from this record.

Uncontrolled Discrete Keywords: antimicrobial agents, metal nanoparticles, bacteria, nanoparticles hydrogels
Subjects: Q Science > QR Microbiology
R Medicine > R Medicine (General)
Divisions: College of Health, Life and Environmental Sciences > School of Science and the Environment
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SWORD Depositor: Prof. Pub Router
Depositing User: Claire Martin
Date Deposited: 06 Feb 2020 15:40
Last Modified: 07 Oct 2020 10:27

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