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Psychotropic Effects of L-theanine and its Clinical Properties: From the Management of Anxiety and Stress to a Potential use in Schizophrenia

Sakamoto, F.L., Ribeiro, R.M.P., Bueno, Allain ORCID: https://orcid.org/0000-0002-9456-8558 and Santos, H.O. (2019) Psychotropic Effects of L-theanine and its Clinical Properties: From the Management of Anxiety and Stress to a Potential use in Schizophrenia. Pharmacological Research, 147. p. 104395. ISSN 1043-6618

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Abstract

Anxiety disorders are highly prevalent in modern societies, and are ranked the sixth most important contributor of non-fatal negative health outcomes. L-theanine is an amino acid naturally found in green tea (Camellia sinensis) and some other plant extracts, and recent clinical studies have proposed promising adjuvant effects of L-theanine for the negative impact of anxiety and psychological stress on health. In this integrative narrative review, we aimed to appraise and further discuss the effects of L-theanine administration on anxiety disorders and psychological stress. Published data suggests that L-theanine administered at daily doses ranging from 200 to 400 mg for up to 8 weeks are safe and induce anxiolytic and anti-stress effects in acute and chronic conditions. L-theanine at doses lower and higher than these may also show promising therapeutic potential; however, a more thorough investigation through randomized double-blind placebo-controlled crossover clinical trials are necessary to elucidate its effects for longer periods, providing further insights for meta-analyses and the development of recommendation guidelines. Additionally, animal studies investigating a higher dosage, its combination with other pharmacological compounds and associated metabolic comorbidities are recommended, as cases of hepatotoxicity associated with the consumption of green tea extract have been reported.

Item Type: Article
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Uncontrolled Keywords: anxiety, Camellia sinensis, green tea, L-theanine, psychological stress, schizophrenia
Subjects: Q Science > QP Physiology
R Medicine > R Medicine (General)
Divisions: Divisions (2019 and before) > Academic Departments > Institute of Science and the Environment
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Depositing User: Allain Bueno
Date Deposited: 19 Aug 2019 15:19
Last Modified: 12 Sep 2019 08:00
URI: https://eprints.worc.ac.uk/id/eprint/8508

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