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Production and Characterisation of Bacterial Cellulose Hydrogels Loaded with Curcumin Encapsulated in Cyclodextrins as Wound Dressings

Gupta, A., Keddie, D.J., Kannappan, V., Gibson, H., Khalil, I.R., Kowalczuk, M., Martin, Claire, Shuai, X. and Radecka, I. (2019) Production and Characterisation of Bacterial Cellulose Hydrogels Loaded with Curcumin Encapsulated in Cyclodextrins as Wound Dressings. European Polymer Journal, 118. 437 - 450. ISSN 0014-3057

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Abstract

Natural bioactive materials with wound healing properties such as curcumin are attracting interest due to the emergence of resistant bacterial strains. The hydrophobicity of curcumin has been counteracted by using solubility enhancing cyclodextrins. Hydrogels facilitate wound healing due to unique properties and 3D network structures which allows encapsulation of healing agents. In this study, biosynthetic cellulose produced by Gluconacetobacter xylinus (ATCC 23770) was loaded with water soluble curcumin:hydroxypropyl-β-cyclodextrin supramolecular inclusion complex produced by a solvent evaporation method to synthesise hydrogel dressings. The ratios of solvents to solubilise curcumin and hydroxypropyl-β-cyclodextrin were tested for the production of the inclusion complex with optimum encapsulation efficacy. The results confirmed that hydroxypropyl-β-cyclodextrin enhanced the aqueous solubility of curcumin and allowed loading into bacterial cellulose hydrogels. These hydrogels were characterised for wound management applications and exhibited haemocompatability, cytocompatability, anti-staphylococcal and antioxidant abilities and therefore support the potential use of the curcumin:hydroxypropyl-β-cyclodextrin-loaded-bacterial cellulose as hydrogel dressings.

Item Type: Article
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Uncontrolled Keywords: biosynthetic hydrogel, curcumin, cyclodextrin, antimicrobial, antioxidant, wound management
Subjects: Q Science > QD Chemistry
Q Science > QR Microbiology
R Medicine > R Medicine (General)
Divisions: Divisions (2019 and before) > Academic Departments > Institute of Science and the Environment
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Depositing User: Claire Martin
Date Deposited: 15 Jul 2019 09:23
Last Modified: 12 Sep 2019 15:36
URI: https://eprints.worc.ac.uk/id/eprint/8344

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