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The Influence of Formulation Components on the Aerosolisation Properties of Spray-dried Powders

Rabbani, N.R. and Seville, Peter C. ORCID: https://orcid.org/0000-0001-8546-3474 (2005) The Influence of Formulation Components on the Aerosolisation Properties of Spray-dried Powders. Journal of Controlled Release, 110 (1). pp. 130-140. ISSN Online: 0168-3659

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Abstract

Dry powders suitable for inhalation containing β-estradiol, leucine as a dispersibility enhancer and lactose as a bulking agent were prepared by spray-drying from aqueous ethanol formulations. The influence of formulation components on the characteristics of the resultant spray-dried powders was examined through the use of a range of ethanol concentrations (10–50% v/v) in the solvent used to prepare the initial formulations. Additionally, the amount of leucine required to act as a dispersibility enhancer was investigated by varying the amount of leucine added to the formulation prior to spray-drying. Following spray-drying, resultant powders were characterised using scanning electron microscopy, laser diffraction and tapped density measurements, and the aerosolisation performance determined using Twin Stage Impinger and Andersen Cascade Impactor analysis. We demonstrate that selection of appropriate solvent systems and leucine concentration allows the preparation of spray-dried powders that display enhanced aerosolisation properties, and would be predicted to exhibit high deposition in the lower regions of the respiratory tract.

Item Type: Article
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Uncontrolled Keywords: spray-drying, viscosity, dry powder, pulmonary drug delivery, leucine
Divisions: Academic Departments > Institute of Science and the Environment
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Depositing User: Peter Seville
Date Deposited: 17 Jun 2019 10:42
Last Modified: 17 Jun 2019 10:42
URI: https://eprints.worc.ac.uk/id/eprint/8192

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