University of Worcester Worcester Research and Publications

Microwaved Bacterial Cellulose-based Hydrogel Microparticles for the Healing of Partial Thickness Burn Wounds

Pandey, M., Mohamad, N., Low, W.L., Martin, Claire and Mohd Amin, M.C.I. (2017) Microwaved Bacterial Cellulose-based Hydrogel Microparticles for the Healing of Partial Thickness Burn Wounds. Drug Delivery and Translational Research, 7 (1). pp. 89-99. ISSN Print: 2190-393X Online 2190-3948

Martin-AAM-2016-Microwaved-bacterial-cellulose-based-hydrogel-particles-for-the-healing-of-partial-thickness-burn-wounds.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (3MB) | Preview


Burn wound management is a complex process because the damage may extend as far as the dermis which has an acknowledged slow rate of regeneration. This study investigates the feasibility of using hydrogel microparticles composed of bacterial cellulose and polyacrylamide as a dressing material for coverage of partial-thickness burn wounds. The microparticulate carrier structure and surface morphology were investigated by Fourier transform infrared, X-ray diffraction, elemental analysis, and scanning electron microscopy. The cytotoxicity profile of the microparticles showed cytocompatibility with L929 cells. Dermal irritation test demonstrated that the hydrogel was non-irritant to the skin and had a significant effect on wound contraction compared to the untreated group. Moreover, histological examination of in vivo burn healing samples revealed that the hydrogel treatment enhanced epithelialization and accelerated fibroblast proliferation with wound repair and intact skin achieved by the end of the study. Both the in vitro and in vivo results proved the biocompatibility and efficacy of hydrogel microparticles as a wound dressing material.

Item Type: Article
Additional Information:

Staff and students at the University of Worcester can access the full-text of the online published version via via the UW online Library Search. External users should check availability with their local library or Interlibrary Requests Service.

Uncontrolled Discrete Keywords: hydrogel microparticles, bacterial cellulose, Cytotoxicity, partial-thickness burn wound, microwave irradiation
Subjects: R Medicine > R Medicine (General)
R Medicine > RL Dermatology
Divisions: College of Health, Life and Environmental Sciences > School of Science and the Environment
Related URLs:
Depositing User: Claire Martin
Date Deposited: 21 May 2019 08:42
Last Modified: 20 Nov 2020 16:51

Actions (login required)

View Item View Item
Worcester Research and Publications is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.