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Characterization and Biocompatibility Evaluation of Bacterial Cellulose-based Wound Dressing Hydrogel: Effect of Electron Beam Irradiation Doses and Concentration of Acrylic Acid

Mohamad, N., Buang, F., Mat Lazim, A., Ahmad, N., Martin, Claire and Mohd Amin, M.C.I. (2016) Characterization and Biocompatibility Evaluation of Bacterial Cellulose-based Wound Dressing Hydrogel: Effect of Electron Beam Irradiation Doses and Concentration of Acrylic Acid. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 105 (8). pp. 2553-2564. ISSN Online:1552-4981

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Abstract

ABSTRACT The use of bacterial cellulose (BC)-based hydrogel has been gaining attention owing to its biocompatibility and biodegradability. This study was designed to investigate the effect of radiation doses and acrylic acid (AA) composition on in vitro and in vivo biocompatibility of BC/AA as wound dressing materials. Physical properties of the hydrogel, that is, thickness, adhesiveness, rate of water vapor transmission, and swelling were measured. Moreover, the effect of these parameters on skin irritation and sensitization, blood compatibility, and cytotoxicity was studied. Increased AA content and irradiation doses increased the thickness, crosslinking density, and improved the mechanical properties of the hydrogel, but reduced its adhesiveness. The swelling capacity of the hydrogel increased significantly with a decrease in the AA composition in simulated wound fluid. The water vapor permeability of polymeric hydrogels was in the range of 2035–2666 g/(m−2 day−1). Dermal irritation and sensitization test demonstrated that the hydrogel was nonirritant and nonallergic. The BC/AA hydrogel was found to be nontoxic to primary human dermal fibroblast skin cells with viability >88\% and was found to be biocompatible with blood with a low hemolytic index (0.80–1.30\%). Collectively, these results indicate that these hydrogels have the potential to be used as wound dressings. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2553–2564, 2017.

Item Type: Article
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Uncontrolled Keywords: hydrogel wound dressing, dermal toxicity, adhesiveness, hemocompatibility
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
R Medicine > RL Dermatology
R Medicine > RM Therapeutics. Pharmacology
Divisions: Divisions (2019 onwards) > College of Health, Life and Environmental Sciences > School of Science and the Environment
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Depositing User: Claire Martin
Date Deposited: 21 May 2019 08:28
Last Modified: 26 Nov 2019 11:26
URI: https://eprints.worc.ac.uk/id/eprint/8011

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