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Agitated Depression in Bipolar Disorder

Serra, Francesca ORCID: https://orcid.org/0000-0003-4758-7585, Gordon-Smith, Katherine ORCID: https://orcid.org/0000-0003-4083-1143, Perry, Amy ORCID: https://orcid.org/0000-0002-9381-6636, Fraser, C., Di Florio, A., Craddock, N., Jones, I. and Jones, Lisa ORCID: https://orcid.org/0000-0002-5122-8334 (2019) Agitated Depression in Bipolar Disorder. Bipolar Disorders. ISSN Print: 1398-5647, Online: 1399-5618 (In Press)

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AGITATED DEPRESSION manuscript (authors accepted version)_11-04-19 with cs.pdf - Accepted Version
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AGITATED DEPRESSION manuscript (authors accepted version)_11-04-19.pdf - Accepted Version
Restricted to Repository staff only

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Abstract

Objectives It has been suggested that agitated depression (AD) is a common, severe feature in bipolar disorder. We aimed to estimate the prevalence of AD and investigate whether presence of AD was associated with episodic and lifetime clinical features in a large well‐characterised bipolar disorder sample. Method The prevalence of agitation, based on semi‐structured interview and medical case‐notes, in the most severe depressive episode was estimated in 2925 individuals with DSM‐IV bipolar disorder recruited into the UK Bipolar Disorder Research Network. Predictors of agitation were ascertained using symptoms within the same episode and lifetime clinical features using multivariate models. Results 32.3% (n=946) experienced agitation during the worst depressive episode. Within the same episode, significant predictors of presence of agitation were: insomnia (OR 2.119, p<.001), poor concentration (OR 1.966, p=.027), decreased libido (OR 1.960, p<.001), suicidal ideation (OR 1.861, p<.001), slowed activity (OR 1.504, p=.001), and poor appetite (OR 1.297, p=.029). Over the lifetime illness course, co‐morbid panic disorder (OR 2.000, p<.001), suicide attempt (OR 1.399, p=.007), and dysphoric mania (OR 1.354, p=.017) were significantly associated with AD. Conclusions Agitation accompanied bipolar depression in at least one‐third of cases in our sample and was associated with concurrent somatic depressive symptoms, which are also common features of mixed manic states. Furthermore, AD in our sample was associated with lifetime experience of mixed mania, in addition to severe lifetime illness course including comorbid panic disorder and suicidal behaviour. Our results have implications for the diagnosis and treatment of agitated features in bipolar depression.

Item Type: Article
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This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/bdi.12778. This article is protected by copyright. All rights reserved.
Staff and students at the University of Worcester can access the full-text via the UW online library search. External users should check availability with their local library or Interlibrary Requests Service.

Uncontrolled Keywords: biological psychiatry, psychiatry and mental health, Psychomotor agitation, bipolar disorder, somatic symptoms, panic disorder, suicide, mixed features, dysphoric mania, agitated depression
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > R Medicine (General)
Divisions: Academic Departments > Institute of Health and Society
Related URLs:
SWORD Depositor: Prof. Pub Router
Depositing User: Katherine Gordon-Smith
Date Deposited: 29 Apr 2019 09:42
Last Modified: 23 May 2019 14:01
URI: https://eprints.worc.ac.uk/id/eprint/7921

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