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Ginkgo Biloba Extract Supplementation Decreases Energy Intake in High Fat Diet Obese Rats But Does Not Modify Tissue Fatty Acid Composition

Hirata, B., Joyce, Ellen, Machado, M.M.F., Bueno, Allain ORCID: https://orcid.org/0000-0002-9456-8558 and Telles, M.M.F. (2019) Ginkgo Biloba Extract Supplementation Decreases Energy Intake in High Fat Diet Obese Rats But Does Not Modify Tissue Fatty Acid Composition. In: 26th European Congress on Obesity, 28th April - 1st May 2019, Glasgow. (Submitted)

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Abstract

INTRODUCTION:
Obesity is a complex disease of multifactorial aetiology, positively associated with metabolic disorders including
hyperinsulinaemia, dyslipidaemia and others. Fatty acids are involved in cell signalling, homeostasis and membrane
composition; however, chronic high saturated fat intake enlarges fat mass and disturbs tissue fatty acid composition.
Supplementation with plant-derived polyphenols may provide therapeutic application for the amelioration of metabolic
disorders. Antioxidant, anti-inflammatory, vasodilatory and anti-oedematogenic properties have been attributed to Ginkgo
biloba extract (GbE). It has been described that GbE supplementation improves insulin sensitivity in adipose tissue of dietinduced
obese rats. However, current understanding of the biochemical pathways modulated by GbE remains limited.
METHODS:
The Committee on Animal Research Ethics, Federal University of São Paulo (Application 271359) authorised this study.
Male rats were fed from 2 to 4-months-old with a high fat diet (HFD) enriched with 28% lard and thereafter supplemented
for 14 days with 500 mg/kg of GbE (HFD+GbE) or saline (HFD). Rats were euthanized and epididymal, retroperitoneal and
mesenteric adipose tissues were removed. Total lipids were extracted using Chloroform/Methanol, methylated and
analysed by Gas Chromatography with Flame Ionization Detector (GC-FID).
RESULTS:
GbE supplementation decreased both food and energy intake comparing to HFD (8.8%, p=0.01). However, no differences
were observed in body weight gain and adipose tissue mass. No significant alterations on tissue fatty acid composition
were observed.
CONCLUSION:
Supplementation with plant-derived polyphenols may provide therapeutic application for obesity, important for patients with
weak adherence to lower calorie diets and positive lifestyle interventions. The current study suggests that GbE
supplementation for two weeks reduces food and energy intake via signalling pathways not associated with adipose tissue
fatty acid composition. Future studies are needed to further elucidate the effects of GbE supplementation for longer periods
of time and its impact on the central nervous system.

Item Type: Conference or Workshop Item (Poster)
Additional Information:

Abstracts from the 26th European Congress on Obesity can be found at https://www.karger.com/Article/Pdf/497797

Subjects: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RZ Other systems of medicine
Divisions: College of Health, Life and Environmental Sciences > School of Science and the Environment
Related URLs:
Depositing User: Allain Bueno
Date Deposited: 24 Apr 2019 10:19
Last Modified: 26 Nov 2019 11:25
URI: https://eprints.worc.ac.uk/id/eprint/7895

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