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Quantifying Between-Cohort and Between-Sex Genetic Heterogeneity in Major Depressive Disorder

Trzaskowski, M., Mehta, D., Peyrot, W., Hawkes, D., Davies, D., Howard, D.M., Kemper, K.E., Sidorenko, J., Maier, R., Ripke, S., Mattheisen, M., Baune, B.T., Grabe, H.J., Heath, A.C., Jones, Lisa, Jones, I., Madden, P.A.F., McIntosh, A.M., Breen, G., Lewis, C.M., Børglum, A.D., Sullivan, P.F., Martin, N.G., Kendler, K.S., Levinson, D.F., Wray, N.R. and Major Depressive Disorder Working Group of the PGC, (2019) Quantifying Between-Cohort and Between-Sex Genetic Heterogeneity in Major Depressive Disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 180 (6). pp. 439-447. ISSN Online: 1552-485X

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Abstract

Major depressive disorder (MDD) is clinically heterogeneous with prevalence rates twice as high in women as in men. There are many possible sources of heterogeneity in MDD most of which are not measured in a sufficiently comparable way across study samples. Here, we assess genetic heterogeneity based on two fundamental measures, between-cohort and between-sex heterogeneity. First, we used genome-wide association study (GWAS) summary statistics to investigate between-cohort genetic heterogeneity using the 29 research cohorts of the Psychiatric Genomics Consortium (PGC; N cases = 16,823, N controls = 25,632) and found that some of the cohort heterogeneity can be attributed to ascertainment differences (such as recruitment of cases from hospital vs community sources). Second, we evaluated between-sex genetic heterogeneity using GWAS summary statistics from the PGC, Kaiser Permanente GERA, UK Biobank and the Danish iPSYCH studies but did not find convincing evidence for genetic differences between the sexes. We conclude that there is no evidence that the heterogeneity between MDD data sets and between sexes reflects genetic heterogeneity. Larger sample sizes with detailed phenotypic records and genomic data remain the key to overcome heterogeneity inherent in assessment of MDD.

Item Type: Article
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Uncontrolled Keywords: MDD, depression, genetic heterogeneity, sex differences, LD score regression
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Academic Departments > Institute of Health and Society
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Depositing User: Katherine Gordon-Smith
Date Deposited: 17 Feb 2019 09:35
Last Modified: 10 Aug 2019 20:30
URI: https://eprints.worc.ac.uk/id/eprint/7573

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