University of Worcester Worcester Research and Publications
 
  USER PANEL:
  ABOUT THE COLLECTION:
  CONTACT DETAILS:

Evidence for Increased Genetic Risk Load for Major Depression in Patients Assigned to Electroconvulsive Therapy

Foo, J.C., Streit, F., Frank, J., Witt, S.H., Truetlein, J., Psychiatric Genomics Consortium, Major Depressive Working Group, Jones, Lisa, Baune, B.T., Moebus, S., Jockel, K-H., Forstner, A.J., Nöthen, M.M., Rietschel, M., Satorius, A. and Kranaster, L. (2018) Evidence for Increased Genetic Risk Load for Major Depression in Patients Assigned to Electroconvulsive Therapy. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 180 (1). pp. 35-45. ISSN 1552-4841 Online: 1552-485X

[img] Text
2018_Foo_NPG_ECT_R2.pdf - Accepted Version
Restricted to Repository staff only

Download (504kB) | Request a copy
[img]
Preview
Text
ajmg.b.32700.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (1MB) | Preview

Abstract

Electroconvulsive therapy (ECT) is the treatment of choice for severe and treatment-resistant depression; disorder severity and unfavorable treatment outcomes are shown to be influenced by an increased genetic burden for major depression (MD). Here, we tested whether ECT assignment and response/nonresponse are associated with an increased genetic burden for major depression (MD) using polygenic risk score (PRS), which summarize the contribution of diseaserelated common risk variants. Fifty-one psychiatric inpatients suffering from a major depressive episode underwent ECT. MD-PRS were calculated for these inpatients and a separate population-based sample (n = 3,547 healthy; n = 426 self-reported depression) based on summary statistics from the Psychiatric Genomics Consortium MDD-working group (Cases: n = 59,851; Controls: n = 113,154). MD-PRS explained a significant proportion of disease status between ECT patients and healthy controls (p = .022, R2 = 1.173%); patients showed higher MD-PRS. MD-PRS in population-based depression self-reporters were intermediate between ECT patients and controls (n.s.). Significant associations between MD-PRS and ECT response (50% reduction in Hamilton depression rating scale scores) were not observed. Our findings indicate that ECT cohorts show an increased genetic burden for MD and are consistent with the hypothesis that treatment-resistant MD patients represent a subgroup with an increased genetic risk for MD. Larger samples are needed to better substantiate these findings.

Item Type: Article
Additional Information:

The full-text of the published version can be accessed via the Official URL.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made

Uncontrolled Keywords: depression, electroconvulsive therapy, major depression, polygenic risk scores, treatment-resistance
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Academic Departments > Institute of Health and Society
Related URLs:
Copyright Info: Open Access Article
Depositing User: Katherine Gordon-Smith
Date Deposited: 12 Dec 2018 12:34
Last Modified: 01 Feb 2019 10:27
URI: https://eprints.worc.ac.uk/id/eprint/7379

Actions (login required)

View Item View Item
 
     
Worcester Research and Publications is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.