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Evidence for Increased Genetic Risk Load for Major Depression in Patients Assigned to Electroconvulsive Therapy

Foo, J.C., Streit, F., Frank, J., Witt, S.H., Truetlein, J., Major Depressive Disorder Working Group of the, Psychiatric Genomics Consortium, Jones, Lisa, Baune, B.T., Moebus, S., Jockel, K-H., Forstner, A.J., Nöthen, M.M., Rietschel, M., Satorius, A. and Kranaster, L. (2018) Evidence for Increased Genetic Risk Load for Major Depression in Patients Assigned to Electroconvulsive Therapy. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 180 (1). pp. 35-45. ISSN 1552-4841 Online: 1552-485X

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Abstract

Electroconvulsive therapy (ECT) is the treatment of choice for severe and treatment-resistant
depression; disorder severity and unfavorable treatment outcomes are shown to be influenced
by an increased genetic burden for major depression (MD). Here, we tested whether ECT assignment
and response/nonresponse are associated with an increased genetic burden for major
depression (MD) using polygenic risk score (PRS), which summarize the contribution of diseaserelated
common risk variants. Fifty-one psychiatric inpatients suffering from a major depressive
episode underwent ECT. MD-PRS were calculated for these inpatients and a separate
population-based sample (n = 3,547 healthy; n = 426 self-reported depression) based on summary
statistics from the Psychiatric Genomics Consortium MDD-working group (Cases:
n = 59,851; Controls: n = 113,154). MD-PRS explained a significant proportion of disease status
between ECT patients and healthy controls (p = .022, R2 = 1.173%); patients showed higher
MD-PRS. MD-PRS in population-based depression self-reporters were intermediate between
ECT patients and controls (n.s.). Significant associations between MD-PRS and ECT response
(50% reduction in Hamilton depression rating scale scores) were not observed. Our findings indicate
that ECT cohorts show an increased genetic burden for MD and are consistent with the
hypothesis that treatment-resistant MD patients represent a subgroup with an increased genetic
risk for MD. Larger samples are needed to better substantiate these findings.

Item Type: Article
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The full-text of the published version can be accessed via the Official URL.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made

Uncontrolled Keywords: depression, electroconvulsive therapy, major depression, polygenic risk scores, treatment-resistance
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: College of Health, Life and Environmental Sciences > School of Allied Health and Community
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Copyright Info: Open Access Article
Depositing User: Katherine Gordon-Smith
Date Deposited: 12 Dec 2018 12:34
Last Modified: 05 Dec 2019 13:23
URI: https://eprints.worc.ac.uk/id/eprint/7379

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