University of Worcester Worcester Research and Publications
 
  USER PANEL:
  ABOUT THE COLLECTION:
  CONTACT DETAILS:

Mood Disorders and Gluten: It’s Not All in Your Mind! A Systematic Review with Meta-Analysis

Busby, E., Bold, Justine, Fellows, Lindsey and Rostami, K. (2018) Mood Disorders and Gluten: It’s Not All in Your Mind! A Systematic Review with Meta-Analysis. Nutrients, 10 (11). p. 1708. ISSN 2072-6643 Online: 2072-6643

[img]
Preview
Text
nutrients-10-01708.pdf - Published Version
Available under License Creative Commons Attribution.

Download (3MB) | Preview

Abstract

Gluten elimination may represent an effective treatment strategy for mood disorders in individuals with gluten-related disorders. However, the directionality of the relationship remains unclear. We performed a systematic review of prospective studies for effects of gluten on mood symptoms in patients with or without gluten-related disorders. Six electronic databases (CINAHL, PsycINFO, Medline, Web of Science, Scopus and Cochrane Library) were searched, from inception to 8 August 2018, for prospective studies published in English. Meta-analyses with random-effects were performed. Three randomised-controlled trials and 10 longitudinal studies comprising 1139 participants fit the inclusion criteria. A gluten-free diet (GFD) significantly improved pooled depressive symptom scores in GFD-treated patients (Standardised Mean Difference (SMD) −0.37, 95% confidence interval (CI) −0.55 to −0.20; p < 0.0001), with no difference in mean scores between patients and healthy controls after one year (SMD 0.01, 95% CI −0.18 to 0.20, p = 0.94). There was a tendency towards worsening symptoms for non-coeliac gluten sensitive patients during a blinded gluten challenge vs. placebo (SMD 0.21, 95% CI −0.58 to 0.15; p = 0.25). Our review supports the association between mood disorders and gluten intake in susceptible individuals. The effects of a GFD on mood in subjects without gluten-related disorders should be considered in future research.

Item Type: Article
Additional Information:

The full-text can be accessed via the Official URL.

Uncontrolled Discrete Keywords: gluten-related disorders, gluten-free diet, coeliac disease, non-coeliac gluten sensitivity, irritable bowel syndrome, mood disorders, affective disorders, depression, major depressive disorder, mental heal, nutition
Subjects: R Medicine > R Medicine (General)
Divisions: College of Health, Life and Environmental Sciences > School of Allied Health and Community
Related URLs:
Copyright Info: Open Access
Depositing User: Justine Bold
Date Deposited: 12 Nov 2018 12:32
Last Modified: 17 Jun 2020 17:25
URI: https://eprints.worc.ac.uk/id/eprint/7293

Actions (login required)

View Item View Item
 
     
Worcester Research and Publications is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.