University of Worcester Worcester Research and Publications
 
  USER PANEL:
  ABOUT THE COLLECTION:
  CONTACT DETAILS:

Plant Polyphenols in Obesity and Obesity-Associated Metabolic Disorders: A Narrative Review of Resveratrol and Flavonoids Upon the Molecular Basis of Inflammation

de Jesus, R.P., Mota, J.F., González-Muniesa, P., Waitzberg, D.L., Telles, M.M. and Bueno, Allain ORCID: https://orcid.org/0000-0002-9456-8558 (2018) Plant Polyphenols in Obesity and Obesity-Associated Metabolic Disorders: A Narrative Review of Resveratrol and Flavonoids Upon the Molecular Basis of Inflammation. Journal of Obesity and Nutritional Disorders, 2018 (129). ISSN 2577-2244

[img]
Preview
Text
Plant Polyphenols in Obesity and Obesity Associated Metabolic Disorders A Narrative Review of Resveratrol and Flavonoids Upon the Molecular Basis of Inflammation.pdf - Published Version
Available under License Creative Commons Attribution.

Download (848kB) | Preview

Abstract

Background: The epidemic of obesity, metabolic syndrome, type 2 diabetes and non-alcoholic fatty liver disease is currently unsustainable for Public Health systems, and preventive and therapeutic approaches are urgently sought to improve health outcomes for affected individuals. Aim: In this study, we aim to further explore and synthetize available evidence on the effects of selected plant polyphenols (PP) upon molecular mechanisms associated with oxidative stress and inflammatory pathways. We also aim to briefly discuss PP supplementation as therapeutic tool for the prevention and management of prevalent obesity-associated metabolic disorders. Methods: This narrative review was performed in the PubMed database in June 2018 without restriction of publication period. Results: PP influence a broad range of cell signalling pathways; by modulating the activity of nuclear transcription factors, PP modulate gene expression and antioxidant responses, as well as inflammation and its resolution. Several interventional studies have investigated the effects of PP supplementation in a variety of sample populations, but no consensus has yet been reached regarding composition, dosage or course of treatment for therapeutic purposes. However, overall results tend to suggest a positive effect of PP in either improving metabolic profile or minimizing negative disease outcomes. Careful consideration on PP supplementation is paramount; adverse effects have already been described. Conclusion: The successful prevention and management or treatment of obesity-associated metabolic disorders may be achieved through an effective multidisciplinary approach to tackle their modifiable risk factors. A balanced diet, which includes naturally occurring sources of PP associated with lower consumption of ultra-processed foods, is a relevant approach for the positive health outcomes desired.

Item Type: Article
Additional Information:

The full-text can be accessed via the Official URL.

Uncontrolled Discrete Keywords: plant polyphenols, inflammation, obesity, metabolic syndrome, non-alcoholic fatty liver disease, diabetes
Subjects: Q Science > QP Physiology
R Medicine > RM Therapeutics. Pharmacology
Divisions: College of Health, Life and Environmental Sciences > School of Science and the Environment
Related URLs:
Copyright Info: Open Access article (UW LS APC)
Depositing User: Allain Bueno
Date Deposited: 10 Oct 2018 11:52
Last Modified: 17 Jun 2020 17:25
URI: https://eprints.worc.ac.uk/id/eprint/7127

Actions (login required)

View Item View Item
 
     
Worcester Research and Publications is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.