Antidepressants for Preventing Postnatal Depression

Molyneux, E., Telesia, L., Henshaw, C., Boath, E., Bradley, Eleanor ORCID: https://orcid.org/0000-0001-5877-2298 and Howard, L. (2018) Antidepressants for Preventing Postnatal Depression. Cochrane Database of Systematic Reviews (4). CD004363. ISSN 1469-493X

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Abstract

Background
Depression is common in the postnatal period and can lead to adverse effects on the infant and wider family, in addition to the morbidity for the mother. It is not clear whether antidepressants are effective for the prevention of postnatal depression and little is known about possible adverse effects for the mother and infant, particularly during breastfeeding. This is an update of a Cochrane
Review last published in 2005.
Objectives
To assess the effectiveness of antidepressant medication for the prevention of postnatal depression, in comparison with any other treatment, placebo or standard care.
Search methods
We searched the Cochrane Common Mental Disorders Controlled Trials Register (CCMDCTR both Studies and References),
CENTRAL (Wiley), MEDLINE (OVID), Embase (OVID), PsycINFO (OVID), on 13 February 2018. We also searched the World
HealthOrganization (WHO) trials portal (ICTRP) and ClinicalTrials.gov on 13 February 2018 to identify any additional unpublished or ongoing studies.
Selection criteria
Randomised controlled trials (RCTs) of initiation of antidepressants (alone or in combination with another treatment), compared with any other treatment, placebo or standard care for the prevention of postnatal depression among women who were either pregnant or had given birth in the previous six weeks and were not currently depressed at baseline.
Data collection and analysis
We used standard methodological procedures expected by Cochrane. We requested missing information from investigators wherever possible and sought data to allow intention-to-treat analyses.

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