University of Worcester Worcester Research and Publications

Acute Responses of Cytokines and Adipokines to Aerobic Exercise in Relapsing vs. Remitting Women with Multiple Sclerosis

Majdinasab, N., Motl, R.W., Mokhtarzade, M., Zimmer, P., Ranjbar, R., Keystman, C., Cullen, Tom, Negaresh, R. and Baker, J.S. (2018) Acute Responses of Cytokines and Adipokines to Aerobic Exercise in Relapsing vs. Remitting Women with Multiple Sclerosis. Complementary Therapies in Clinical Practice, 31. pp. 295-301. ISSN 1744-3881 Online: 1873-6947

complementary therapies article.pdf - Accepted Version

Download (815kB) | Preview


Objective: To examine the acute effect of exercise on cytokines and adipokines during relapse and the remitting
phase of multiple sclerosis (MS).
Methods: Thirty women with MS in the relapsing or remitting phase were matched with fifteen healthy controls.
Participants performed a single-bout of aerobic exercise at 60-70% maximal heart rate. Furthermore, five women in
the relapsing phase were enrolled (control relapse) and did not receive any intervention. Blood samples were taken
before, immediately after, 1-hour and 6-hours after the exercise.
Results: Levels of IL-10 and TNF-α in response to exercise were similar in healthy and MS remitting subjects.
Compared to baseline, TNF-α levels in relapsing subjects were significantly decreased immediately after exercise.
Immediately following exercise, leptin levels significantly decreased in relapsing subjects. Adiponectin and IL-6
showed no significant difference between groups.
Conclusion: After relapse, exercise does not induce inflammatory cytokine response and temporarily improves both
cytokine and adipokine balance.

Item Type: Article
Additional Information:

Staff and students at the University of Worcester can access the full-text via the UW online library search. External users should check availability with their local library or Interlibrary Requests Service.

Uncontrolled Discrete Keywords: multiple sclerosis, cytokines, inflamation, adipokines, aerobic interval exercise
Subjects: Q Science > QP Physiology
Divisions: College of Business, Psychology and Sport > School of Sport and Exercise Science
Depositing User: Tom Cullen
Date Deposited: 27 Mar 2018 07:59
Last Modified: 12 Oct 2020 11:59

Actions (login required)

View Item View Item
Worcester Research and Publications is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.