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Genome-wide Significant Locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar Type

Green, E.K., Di Florio, A., Forty, L., Gordon-Smith, Katherine, Grozeva, D., Fraser, C., Richards, A., Moran, J.L., Purcell, S., Sklar, P., Kirov, G., Owen, M.J., O'Donovan, M.C., Craddock, N., Jones, Lisa and Jones, I.R. (2017) Genome-wide Significant Locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar Type. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 174 (8). pp. 767-771. ISSN 1552-485X

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Abstract

Studies have suggested that Research Diagnostic Criteria for Schizoaffective Disorder Bipolar type (RDC-SABP) might identify a more genetically homogenous subgroup of bipolar disorder. Aiming to identify loci associated with RDC-SABP, we have performed a replication study using independentRDC-SABP cases (n = 144) and controls (n = 6,559), focusing on the 10 loci that reached a p-value <10−5 for RDCSABP in the Wellcome Trust Case Control Consortium (WTCCC) bipolar disorder sample. Combining theWTCCC and replication datasets by meta-analysis (combined RDC-SABP, n = 423, controls, n = 9,494), we observed genome-wide significant association at one SNP, rs2352974, located within the intron of the gene TRAIP on chromosome 3p21.31 (p-value, 4.37 × 10−8). This locus did not reach genome-wide significance in bipolar disorder or schizophrenia large Psychiatric Genomic Consortium datasets, suggesting that it may represent a relatively specific genetic risk for the bipolar subtype of schizoaffective disorder.

Item Type: Article
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Uncontrolled Keywords: Research Diagnostic Criteria, SABP, schizoaffective disorder bipolar type, TRAIP
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Academic Departments > Institute of Health and Society
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Depositing User: Katherine Gordon-Smith
Date Deposited: 30 Aug 2017 15:05
Last Modified: 28 Feb 2018 01:00
URI: https://eprints.worc.ac.uk/id/eprint/5844

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