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Genome-wide Significant Locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar Type

Green, E.K. and Di Florio, A. and Forty, L. and Gordon-Smith, Katherine and Grozeva, D. and Fraser, C. and Richards, A. and Moran, J.L. and Purcell, S. and Sklar, P. and Kirov, G. and Owen, M.J. and O'Donovan, M.C. and Craddock, N. and Jones, Lisa and Jones, I.R. (2017) Genome-wide Significant Locus for Research Diagnostic Criteria Schizoaffective Disorder Bipolar Type. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. ISSN 1552-485X (In Press)

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Abstract

Studies have suggested that Research Diagnostic Criteria for Schizoaffective Disorder Bipolar type (RDC-SABP) might identify a more genetically homogenous subgroup of bipolar disorder. Aiming to identify loci associated with RDC-SABP, we have performed a replication study using independentRDC-SABP cases (n = 144) and controls (n = 6,559), focusing on the 10 loci that reached a p-value <10−5 for RDCSABP in the Wellcome Trust Case Control Consortium (WTCCC) bipolar disorder sample. Combining theWTCCC and replication datasets by meta-analysis (combined RDC-SABP, n = 423, controls, n = 9,494), we observed genome-wide significant association at one SNP, rs2352974, located within the intron of the gene TRAIP on chromosome 3p21.31 (p-value, 4.37 × 10−8). This locus did not reach genome-wide significance in bipolar disorder or schizophrenia large Psychiatric Genomic Consortium datasets, suggesting that it may represent a relatively specific genetic risk for the bipolar subtype of schizoaffective disorder.

Item Type: Article
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Uncontrolled Keywords: Research Diagnostic Criteria, SABP, schizoaffective disorder bipolar type, TRAIP
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Academic Departments > Institute of Health and Society
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Depositing User: Katherine Gordon-Smith
Date Deposited: 30 Aug 2017 15:05
Last Modified: 30 Aug 2017 15:05
URI: https://eprints.worc.ac.uk/id/eprint/5844

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