University of Worcester Worcester Research and Publications
 
  USER PANEL:
  ABOUT THE COLLECTION:
  CONTACT DETAILS:

Factors Influencing Post-exercise Plasma Protein Carbonyl Concentration

Wadley, Alex and Aldred, S. and Turner, J.E. (2016) Factors Influencing Post-exercise Plasma Protein Carbonyl Concentration. Free Radical Research, 50 (4). ISSN 1071-5762 Online: 1029-2470

[img] Text (PDF)
2016 Wadley Free Rad Res review protein carbonyls exercise.pdf - Published Version
Restricted to Repository staff only

Download (1MB) | Request a copy

Abstract

Exercise of sufficient intensity and duration can cause acute oxidative stress. Plasma protein carbonyl (PC) moieties are abundant, chemically stable, and easily detectable markers of oxidative stress that are widely used for the interpretation of exercise-induced changes in redox balance. Despite many studies reporting acute increases in plasma PC concentration in response to exercise, some studies, including those from our own laboratory have shown decreases. This review will discuss the differences between studies reporting increases, decreases, and no change in plasma PC concentration following exercise in humans; highlighting participant physiology (i.e. training status) and study design (i.e. intensity, duration, and novelty of the exercise bout) as the main factors driving the direction of the PC response to exercise. The role of the 20S proteasome system is proposed as a possible mechanism mediating the clearance of plasma PC following exercise. Resting and exercise-induced differences in plasma protein composition and balance between tissues are also discussed. We suggest that exercise may stimulate the clearance of plasma PC present at baseline, whereas simultaneously increasing reactive oxygen species production that facilitates the formation of new PC groups. The balance between these two processes likely explains why some studies have reported no change or even decreases in plasma PC level postexercise when other biomarkers of oxidative stress (e.g. markers of lipid peroxidation) were elevated. Future studies should determine factors that influence the balance between PC clearance and formation following acute exercise.

Item Type: Article
Additional Information:

The full-text cannot be supplied for this item. Please check availability with your local library or Interlibrary Requests Service.

Uncontrolled Keywords: plasma protein carbonyl (PC), oxidative stress, exercise-induced changes in redox balance, exercise, human biology, exercise, proteasome, protein degradation, protein oxidation, reactive oxygen species
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Academic Departments > Institute of Science and the Environment
Related URLs:
Depositing User: Alex Wadley
Date Deposited: 22 Nov 2016 08:19
Last Modified: 22 Nov 2016 08:19
URI: https://eprints.worc.ac.uk/id/eprint/5089

Actions (login required)

View Item View Item
 
     
Worcester Research and Publications is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.