University of Worcester Worcester Research and Publications

Factors Influencing Post-exercise Plasma Protein Carbonyl Concentration

Wadley, Alex, Aldred, S. and Turner, J.E. (2016) Factors Influencing Post-exercise Plasma Protein Carbonyl Concentration. Free Radical Research, 50 (4). ISSN 1071-5762 Online: 1029-2470

[img] Text (PDF)
2016 Wadley Free Rad Res review protein carbonyls exercise.pdf - Published Version
Restricted to Repository staff only

Download (1MB) | Request a copy


Exercise of sufficient intensity and duration can cause acute oxidative stress. Plasma protein
carbonyl (PC) moieties are abundant, chemically stable, and easily detectable markers of oxidative
stress that are widely used for the interpretation of exercise-induced changes in redox balance.
Despite many studies reporting acute increases in plasma PC concentration in response to exercise,
some studies, including those from our own laboratory have shown decreases. This review will
discuss the differences between studies reporting increases, decreases, and no change in plasma
PC concentration following exercise in humans; highlighting participant physiology (i.e. training
status) and study design (i.e. intensity, duration, and novelty of the exercise bout) as the main
factors driving the direction of the PC response to exercise. The role of the 20S proteasome system
is proposed as a possible mechanism mediating the clearance of plasma PC following exercise.
Resting and exercise-induced differences in plasma protein composition and balance between
tissues are also discussed. We suggest that exercise may stimulate the clearance of plasma PC
present at baseline, whereas simultaneously increasing reactive oxygen species production that
facilitates the formation of new PC groups. The balance between these two processes likely
explains why some studies have reported no change or even decreases in plasma PC level postexercise
when other biomarkers of oxidative stress (e.g. markers of lipid peroxidation) were
elevated. Future studies should determine factors that influence the balance between PC clearance
and formation following acute exercise.

Item Type: Article
Additional Information:

Staff and students at the University of Worcester can access the full-text of the online published article via the official URL. External users should check availability with their local library or Interlibrary Requests Service.

Uncontrolled Discrete Keywords: plasma protein carbonyl (PC), oxidative stress, exercise-induced changes in redox balance, exercise, human biology, exercise, proteasome, protein degradation, protein oxidation, reactive oxygen species
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: College of Health, Life and Environmental Sciences > School of Science and the Environment
Related URLs:
Depositing User: Alex Wadley
Date Deposited: 22 Nov 2016 08:19
Last Modified: 17 Jun 2020 17:14

Actions (login required)

View Item View Item
Worcester Research and Publications is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.