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Psychiatric Genome-wide Association Study Analyses Implicate Neuronal, Immune and Histone Pathways

The Network and Pathway Analysis Subgroup, Psychiatric Genomics Consortium, Jones, Lisa and Gordon-Smith, Katherine (2015) Psychiatric Genome-wide Association Study Analyses Implicate Neuronal, Immune and Histone Pathways. Nature Neuroscience, 18 (2). pp. 199-209. ISSN Print: 1097-6256 Online:1546-1726

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Abstract

Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple genetic associations with such disorders, but better methods are needed to derive the underlying biological mechanisms that these signals indicate. We sought to identify biological pathways in GWAS data from over 60,000 participants from the Psychiatric Genomics Consortium. We developed an analysis framework to rank pathways that requires only summary statistics. We combined this score across disorders to find common pathways across three adult psychiatric disorders: schizophrenia, major depression and bipolar disorder. Histone methylation processes showed the strongest association, and we also found statistically significant evidence for associations with multiple immune and neuronal signaling pathways and with the postsynaptic density. Our study indicates that risk variants for psychiatric disorders aggregate in particular biological pathways and that these pathways are frequently shared between disorders. Our results confirm known mechanisms and suggest several novel insights into the etiology of psychiatric disorders.

Item Type: Article
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Citation for this article:-
Network, T. and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium, 2015. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nature neuroscience, 18(2), pp.199-209.

Uncontrolled Keywords: psychiatric disorders, genome-wide association study, neuronal pathways, immune pathways, histone pathways
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: Academic Departments > Institute of Health and Society
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Depositing User: Lisa Jones
Date Deposited: 07 Nov 2016 08:45
Last Modified: 07 Nov 2016 09:16
URI: https://eprints.worc.ac.uk/id/eprint/5046

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