University of Worcester Worcester Research and Publications

Psychiatric Genome-wide Association Study Analyses Implicate Neuronal, Immune and Histone Pathways

The Network and Pathway Analysis Subgroup, Psychiatric Genomics Consortium, Jones, Lisa ORCID: and Gordon-Smith, Katherine ORCID: (2015) Psychiatric Genome-wide Association Study Analyses Implicate Neuronal, Immune and Histone Pathways. Nature Neuroscience, 18 (2). pp. 199-209. ISSN Print: 1097-6256 Online:1546-1726

Full text not available from this repository. (Request a copy)


Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple genetic associations with such disorders, but better methods are needed to derive the underlying biological mechanisms that these signals indicate. We sought to identify biological pathways in GWAS data from over 60,000 participants from the Psychiatric Genomics Consortium. We developed an analysis framework to rank pathways that requires only summary statistics. We combined this score across disorders to find common pathways across three adult psychiatric disorders: schizophrenia, major depression and bipolar disorder. Histone methylation processes showed the strongest association, and we also found statistically significant evidence for associations with multiple immune and neuronal signaling pathways and with the postsynaptic density. Our study indicates that risk variants for psychiatric disorders aggregate in particular biological pathways and that these pathways are frequently shared between disorders. Our results confirm known mechanisms and suggest several novel insights into the etiology of psychiatric disorders.

Item Type: Article
Additional Information:

Staff and students at the University of Worcester can access the full-text via the UW online library search. External users should check availability with their local library or Interlibrary Requests Service.
Citation for this article:-
Network, T. and Pathway Analysis Subgroup of the Psychiatric Genomics Consortium, 2015. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nature neuroscience, 18(2), pp.199-209.

Uncontrolled Discrete Keywords: psychiatric disorders, genome-wide association study, neuronal pathways, immune pathways, histone pathways
Subjects: B Philosophy. Psychology. Religion > BF Psychology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Divisions: College of Health, Life and Environmental Sciences > School of Allied Health and Community
Related URLs:
Depositing User: Lisa Jones
Date Deposited: 07 Nov 2016 08:45
Last Modified: 17 Jun 2020 17:14

Actions (login required)

View Item View Item
Worcester Research and Publications is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.